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ID 117015
タイトル別表記
Biotin levels in blood and follicular fluid
著者
Yanagihara, Rie Tokushima University
野口, 拓樹 Tokushima University
Yano, Yuya Tokushima University
Hayashi, Noriko Tokushima University
Ohta, Chiaki Tokushima University
Aoki, Hidenori Tokushima University
Tamura, Kou Tokushima University
Masaki, Rie Tokushima University
Tachibana, Ayaka Tokushima University
キーワード
biotin
IVF/ICSI
follicular fluid
pregnancy
資料タイプ
学術雑誌論文
抄録
It has been shown that biotin, a water-soluble vitamin (B7), plays roles in reproductive functions, such as oocyte maturation and embryo development, in experimental animals. On the other hand, little is known about the clinical effects of biotin on human reproduction. In this study, serum and follicular fluid biotin levels were measured in patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI), and their associations with reproductive outcomes were evaluated. As a result, biotin was detected in follicular fluid, as well as serum, and the biotin levels of follicular fluid were found to be positively correlated with those of serum. The biotin levels of serum were higher than those of follicular fluid, suggesting that biotin may be taken up into the follicular fluid from the blood. Although serum and follicular fluid biotin levels tended to be higher in pregnant patients than in non-pregnant patients, these data did not show the significant statistical difference. These findings indicate that biotin does not contribute to the maintenance of oocyte quality, and hence, it does not increase fertilization and pregnancy rates.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
69
1-2
開始ページ
65
終了ページ
69
並び順
65
発行日
2022-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系