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ID 114929
タイトル別表記
Elastin Variants in Two Angiographic PCV Subtypes
著者
Yanagisawa, Suiho Kobe University
Sakurada, Yoichi University of Yamanashi
Miki, Akiko Kobe University
Matsumiya, Wataru Kobe University
井本, 逸勢 The University of Tokushima KAKEN研究者をさがす
Honda, Shigeru Kobe University
資料タイプ
学術雑誌論文
抄録
Objective
To compare the association of elastin (ELN) gene variants between two different angiographic phenotypes of polypoidal choroidal vasculopathy (PCV).
Methods
We included 411 treatment-naïve PCV patients and 350 controls in the present study. PCV was classified into two phenotypes (152 Type 1 and 259 Type 2) according to the presence or absence of feeding vessels found in indocyanine-green angiography. Single nucleotide polymorphisms (SNPs) in the ELN region including rs868005, rs884843, rs2301995, rs13239907 and rs2856728 were genotyped using TaqMan Genotyping Assays.
Results
In the allelic association analyses, rs868005 showed the strongest association with Type 2 PCV (allelic odds ratio 1.56; p = 7.4x10-6), while no SNP was significantly associated with Type 1 PCV. Genotype association analyses revealed the significant association of rs868005 with Type 2 PCV in log additive model and predominant model (odds ratio 1.75; p = 1.5x10-6 and odds ratio 1.60; p = 0.0044, respectively), but not with Type 1 PCV. These findings were further corroborated by another control group in the literature.
Conclusions
There may be significantly different associations in genetic variants of elastin between two angiographic phenotypes of PCV.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
10
3
開始ページ
e0120643
発行日
2015-03-16
権利情報
© 2015 Yanagisawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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言語
eng
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部局
医学系