ID 109999
著者
佐藤, 陽一 Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
田嶋, 敦 Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University
カツラヤマ, モトキ Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School
ノザワ, シアリ Department of Urology, St. Marianna University School of Medicine
ヨシイケ, ミキ Department of Urology, St. Marianna University School of Medicine
Koh, Eitetsue Department of Urology, Kanazawa University Graduate School of Medical Sciences
カナヤ, ジロウ Department of Urology, Kanazawa University Graduate School of Medical Sciences
ナミキ, ミキオ Department of Urology, Kanazawa University Graduate School of Medical Sciences
マツミヤ, キヨミ Department of Urology, Suita Tokushukai Hospital
ツジムラ, アキラ Department of Urology, Graduate School of Medicine, Faculty of Medicine, Osaka University
コマツ, キヨシ Department of Urology, Harasanshinkai Hospital
イトウ, ナオキ Department of Urology, Sapporo Medical University
エグチ, ジロウ Department of Urology, Nagasaki University
井本, 逸勢 Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
山内, あい子 Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
イワモト, テルアキ Department of Urology, St. Marianna University School of Medicine|Center for Infertility and IVF, International University of Health and Welfare Hospital
資料タイプ
学術雑誌論文
抄録
In men, follicle-stimulating hormone (FSH) acts on the seminiferous tubules and enhances spermatogenesis. Recently, a candidate locus (rs2414095) for FSH levels was identified by a genome-wide association study (GWAS) in Chinese men. The rs2414095 SNP is found on the third intron of the cytochrome P450, family 19, subfamily A, peptide 1 (CYP19A1) gene encoding an aromatase. In the present study, we performed a replication study in 1687 Japanese men (901 from cohort 1 and 786 from cohort 2) to assess whether this single nucleotide polymorphism (SNP) is associated with circulating FSH levels. Furthermore, we investigated whether the rs2414095 SNP is correlated with semen quality traits in 2015 Japanese men (1224 from cohort 1 and 791 from cohort 2). The rs2414095 SNP was significantly associated with circulating FSH levels (βSTD = 0.15, P = 9.7 × 10-5), sperm concentration (βSTD = 0.073, P = 0.032), and total sperm number (TSN) (βSTD = 0.074, P = 0.027) in a combined analysis of the two Japanese male cohorts. We successfully replicated, in Japanese men, the results of the previous GWAS for the rs2414095 SNP in Chinese men, and found that the rs2414095 SNP was related with sperm production.
掲載誌名
Journal of Human Genetics
ISSN
14345161
cat書誌ID
AA11206160
61
11
開始ページ
911
終了ページ
915
並び順
911
発行日
2016-11
備考
Running title : Candidate polymorphism associated with FSH levels

© 2016 The Japan Society of Human Genetics

論文本文 : LID201701242001.pdf
Table 1 : LID201701242002.pdf
Table 2 : LID201701242003.pdf
Table 3 : LID201701242004.pdf
EDB ID
出典
Journal of Human Genetics (2016) Vol.61 No.11 p.911-915
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系
医学系