ID 109521
タイトル別表記
グルタミンは抗癌剤起因性腸炎モデルラットの小腸粘膜を保護する
Glutamine protects small intestinal mucosa
著者
武知, 浩和 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧 KAKEN研究者をさがす
原田, 永勝 the University of Tokushima KAKEN研究者をさがす
アサクラ, メグミ the University of Tokushima
ミナト, タクヤ the University of Tokushima
古北, 由仁 the University of Tokushima
山本, 洋太 the University of Tokushima KAKEN研究者をさがす
ユアサ, ヤスヒロ the University of Tokushima
ヤマイ, ヒロミチ the University of Tokushima
清家, 純一 the University of Tokushima
キーワード
glutamine
gastrointestinal toxity
anticancer drug
diamine oxidase
IgA
資料タイプ
学位論文
抄録
Supportive therapy during chemotherapy has become essential, but effective preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model. In this study, we used twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered at 20mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber and oligosaccharide (GFO[○R]) (1000 mg/kg/day) groups. All groups were sacrificed on day 6 and upper jejunums were excised. The jejunal villous height was measured in specimens. IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured. The jejunal villous height was recognized as shorter in the specimen from 5-FU treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase activity in 5-FU+glutamine group were significantly superior to that in 5-FU group (p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity and IgA level in jejunal washing solution showed no significant difference between 5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
61
1-2
開始ページ
59
終了ページ
64
並び順
59
発行日
2014-02
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201405131006.pdf
論文本文 : LID201405281003.pdf
本論文は,著者Hirokazu Takechiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2742号
学位記番号
甲医第1203号
学位授与年月日
2014-03-19
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系
生物資源系