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ID 114969
タイトル別表記
部分的上皮間葉転換関連遺伝子による頭頚部扁平上皮癌の予後予測
Prognostic value of partial-EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis
Prognostic value of p-EMT-related genes in HNSCC
著者
木曽田, 暁 徳島大学大学院口腔科学教育部(口腔科学専攻)
Shao, Wenhua Tokushima University
Jin, Shengjian Tokushima University
キーワード
Head and neck squamous cell carcinoma
Partial-epithelial-to-mesenchymal transition
prognosis
資料タイプ
学位論文
抄録
Objective: Recent studies have revealed that the ability of cancer cells to undergo intermediate state of EMT, partial EMT (p-EMT) poses a higher metastatic risk rather than complete EMT. Here we examined the prognostic value of p-EMT-related genes in head and neck squamous cell carcinoma (HNSCC) by bioinformatics approaches.
Materials and Methods: We used RNA-seq data of 519 primary HNSCC cases obtained from TCGA database. We compared the expression of p-EMT-related genes in HNSCC tissues with normal tissues. We evaluated the prognostic value of p-EMT-related genes in HNSCC cases by Log-rank test. We examined the expression of p-EMT-, EMT-, and epithelial differentiation-related genes by qPCR.
Results: Among p-EMT-related genes that were highly expressed in HNSCC cases, high expression of SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 was significantly correlated with poor survival of HNSCC patients. By gene expression pattern, HNSCC cell lines were classified into three groups; epithelial phenotype, EMT-phenotype, and p-EMT phenotype.
Conclusions: Our findings suggest that p-EMT program may be involved in poor prognosis of HNSCC. SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 can be used for a prognostic marker. Moreover, HNSCC cells with p-EMT phenotype can be a useful model for investigating a nature of p-EMT.
掲載誌名
Oral Diseases
ISSN
16010825
cat書誌ID
AA11631042
出版者
John Wiley & Sons
26
6
開始ページ
1149
終了ページ
1156
発行日
2020-04-11
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Satoru Kisodaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This is the peer reviewed version of the following article: Kisoda, S, Shao, W, Fujiwara, N, et al. Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis. Oral Dis. 2020; 26: 1149– 1156., which has been published in final form at https://doi.org/10.1111/odi.13351. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3611号
学位記番号
甲口第479号
学位授与年月日
2022-03-23
学位名
博士(歯学)
学位授与機関
徳島大学
部局
歯学系
医学系