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ID 113355
タイトル別表記
十分量の高脂肪食の摂取はストレス誘発性の社会回避行動を改善する
著者
大塚, 愛理 徳島大学大学院医科学教育部(医学専攻)
キーワード
社会敗北性ストレス
高脂肪食
HPA軸
コルチコステロン
脂質代謝
social defeat stress
social avoidance
high-fat diet
HPA axis
depression
anxiety
資料タイプ
学位論文
抄録
Aims: Psychosocial stress is a form of mental stress associated with human relationships that underlies the pathogenesis of mental disorders such as depression. Previous studies have suggested that intake of energy-dense foods, also known as “palatable foods,” can relieve psychosocial stress. However, it remains unclear whether the volume of palatable food affects abnormal behavior induced by psychosocial stress. In the present study, we aimed to determine whether levels of high-fat food intake significantly influence psychosocial stress using the social-defeat stress (SDS) paradigm.
Main methods: Mice subjected to SDS ate either a high-fat or normal chow diet for 10 days. Behavioral tests were conducted following the completion of the SDS paradigm. The hypothalamus, liver, and blood were examined post-mortem.
Key findings: Mice with sufficient intake of high-fat chow immediately following exposure to SDS did not exhibit social avoidance behavior, suggesting that a high-fat diet may improve social behavior. However, inadequate intake of high-fat food, which did not alter cholesterol metabolism or hypothalamic-pituitary-adrenal axis activity, was not associated with such benefits, instead increased anxiety-like behavior.
Significance: The results of the present study demonstrate that eating a high-fat diet may attenuate stress, but that this benefit disappears with insufficient intake of high-fat foods. The benefits of a high-fat diet under SDS may be related to cholesterol metabolism in the liver.
掲載誌名
Life Sciences
ISSN
00243205
cat書誌ID
AA11536551
出版者
Elsevier
219
開始ページ
219
終了ページ
230
発行日
2019-01-14
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Airi Otsukaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3260号
学位記番号
甲医第1409号
学位授与年月日
2019-03-22
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系