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ID 114637
タイトル別表記
ペルオキシソーム増殖因子活性化受容体アルファノックアウトマウスの絶食時における睡眠変化
著者
近藤, 慶承 徳島大学大学院医科学教育部(医学専攻)
Tanioka, Daisuke Tokushima University
Uguisu, Haruo Tokushima Bunri University
キーワード
PPARα
Sleep
Food deprivation
Ketone bodies
資料タイプ
学位論文
抄録
Peroxisome proliferator-activated receptor alpha (PPARα) is a transcription factor that belongs to the nuclear receptor family and plays an important role in regulating gene expression associated with lipid metabolism. PPARα promotes hepatic fatty acid oxidation and ketogenesis in response to fasting. Because energy metabolism is known to affect sleep regulation, manipulations that change PPARα are likely to affect sleep and other physiological phenotypes. In this study, we examined the role of PPARα in sleep/wake regulation using PPARα knockout (KO) mice. Sleep, body temperature (BT), locomotor activity, arterial pressure (AP) and heart rate (HR) were recorded in KO mice and wild-type (WT) controls under ad libitum-fed conditions and 24-hour food deprivation (FD). KO and WT mice were identical in basal sleep amount, BT, mean AP and HR, although KO mice showed enhanced sleepiness (enhanced EEG slow-wave activity). In response to FD, KO mice showed a large drop in wakefulness and locomotor activity at the end of the dark phase, whereas WT mice did not. Similarly, AP and HR, which were suppressed by FD, decreased more in KO than in WT mice. Compared to WT mice, KO mice showed a reduced concentration of plasma ketone bodies and decreased mRNA expression of the ketogenic enzyme gene Hmgcs2 in the liver and brain under FD conditions. These results suggest that PPARα and/or lipid metabolism is involved in the maintenance of wakefulness and locomotor activity during fasting in mice.
掲載誌名
Physiology & Behavior
ISSN
00319384
cat書誌ID
AA11537135
AA00352932
出版者
Elsevier
214
開始ページ
112760
発行日
2019-11-27
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yoshitsugu Kondoの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3365号
学位記番号
甲医第1448号
学位授与年月日
2020-03-18
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系