直近一年間の累計
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ID 116547
タイトル別表記
Dynapenia and sarcopenia diabetes
著者
Yasuda, Tetsuyuki Osaka Police Hospital
Umayahara, Yutaka Osaka General Medical Center
Shimizu, Sayoko Osaka General Medical Center
Ryomoto, Kayoko Osaka Rosai Hospital
Yoshiuchi, Kazutomi Osaka Kaisei Hospital
Yamamoto, Tsunehiko Kansai Rosai Hospital
Matsuoka, Taka-aki Osaka University
Shimomura, Iichiro Osaka University
キーワード
Dynapenia
Sarcopenia
Type 1 and type 2 diabetes
資料タイプ
学術雑誌論文
抄録
Aims/Introduction: The present study aimed to clarify the prevalence and clinical characteristics of sarcopenia and dynapenia, which are muscle weakness with and without low muscle mass, respectively, in Japanese patients with type 1 diabetes mellitus and type 2 diabetes mellitus.
Materials and Methods: This cross-sectional study enrolled 1,328 participants with type 1 diabetes (n = 177), type 2 diabetes (n = 645) and without diabetes (n = 506). Sarcopenia was defined as a low grip strength and slow gait speed with low skeletal muscle mass index, whereas dynapenia was defined as low strengths of grip and knee extension with a normal skeletal muscle mass index. Participants without sarcopenia and dynapenia were defined as robust.
Results: Among participants aged ≥65 years, sarcopenia and dynapenia were observed in 12.2% and 0.5% of individuals without diabetes, 42.9% and 11.4% of type 1 diabetes patients, and 20.9% and 13.9% of type 2 diabetes patients. In both type 1 diabetes and type 2 diabetes patients, sarcopenic patients were significantly older and thinner, and showed a significantly higher rate of diabetic neuropathy than robust patients. In patients with type 1 diabetes and type 2 diabetes, dynapenic patients were older, and showed a higher rate of diabetic neuropathy and lower estimated glomerular filtration rate than robust patients. Patients complicated with sarcopenia and dynapenia showed a significantly lower physical quality of life and higher rate of incidental falls than robust patients.
Conclusions: Sarcopenia and dynapenia were more frequent in patients with type 1 diabetes and type 2 diabetes than in individuals without diabetes, which might contribute to their impaired quality of life and incidental falls.
掲載誌名
Journal of Diabetes Investigation
ISSN
20401124
cat書誌ID
AA12488319
出版者
Asian Association for the Study of Diabetes|John Wiley & Sons
12
6
開始ページ
1050
終了ページ
1059
発行日
2020-10-16
権利情報
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所
医学系