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ダウンロード数 : ?
ID 78648
著者
サカキ, マナブ Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School|Department of Urology, Kamei Hospital
福森, 知治 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School KAKEN研究者をさがす
布川, 朋也 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Elsamman, Essam Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School
Shiirevnyamba, Avirmed Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School
中逵, 弘能 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School
金山, 博臣 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
clear cell renal cell carcinoma
galectin-3
prognosis
資料タイプ
学術雑誌論文
抄録
Overexpression of galectin-3 in a variety of cancer cell lines has been shown
to correlate with tumor progression and metastasis. In this study, we investigated the
expression of galectin-3 in clear cell renal cell carcinoma (CC-RCC) and evaluated the
relationship between galectin-3 expression levels and the clinicopathological features
of CC-RCC. Expression of galectin-3 in the kidney cancer cell lines Caki-1, Caki-2, A704,
ACHN and KPK-1 were evaluated using western blot analysis, while galectin-3 expression
in CC-RCC tissues and normal parenchyma were measured by real-time PCR and
immunohistochemistry. We found that galectin-3 was overexpressed in the Caki-1, Caki-
2, A704, ACHN and KPK-1 cell lines and that the expression level in CC-RCC was also
significantly higher than that in renal parenchyma obtained from the same patient samples
(p=0.039). Galectin-3 expression in CC-RCC with distant metastasis was also significantly
higher than that in CC-RCC without distant metastasis (p=0.045). In conclusion,
we revealed that galectin-3 is highly expressed in CC-RCC, especially in CC-RCC
with distant metastasis, suggesting that galectin-3 may serve as a novel target molecule
for predicting CC-RCC metastasis.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
1-2
開始ページ
152
終了ページ
157
並び順
152
発行日
2010-02
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
フルテキストファイル
言語
eng
部局
病院
医学系