岡田, 直人 Tokushima University KAKEN研究者をさがす
Kobayashi, Shinya Tokushima University
Moriyama, Kouta Tokushima University
Miyataka, Kohsuke Tokushima University
阿部, 真治 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
佐藤, 智恵美 Tokushima University 徳島大学 教育研究者総覧
川添, 和義 Tokushima University KAKEN研究者をさがす
Hepatic lipid profile
Objectives: To analyze the effects of feeding Helianthus tuberosus (HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet (HFD).
Methods: A normal HFD or HFD including 10 w/w% HT tubers (HFD + HT) was fed to F334/Jcl rats. After 10 weeks, organ weights, glucose tolerance, and lipid profile were analyzed.
Results: The body weight, liver weight, and epidermal fat content in the HFD group were higher than those of the normal group, and similar to those of the HFD + HT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 min after beginning the test in the HFD + HT group was significantly lower than that in the HFD group. Liver triglyceride and total cholesterol levels in the HFD + HT group were significantly lower than those in the HFD group. Fecal triglyceride and total cholesterol levels in the HFD + HT group were higher than those in the HFD group. Histological analyses revealed that fat and glycogen accumulation increased in the HFD group, but decreased in the HFD + HT group.
Conclusions: These results indicate that HT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile.
Asian Pacific Journal of Tropical Medicine
Hainan Medical College|Elsevier
© 2017 Hainan Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
apjtm_10_5_439.pdf 699 KB