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ID 106070
タイトル別表記
Augmentation indexは高齢者の冠動脈疾患のリスクを評価し得ない
Augmentation Index in CAD
著者
林, 修司 徳島大学大学院医科学教育部(医学専攻)
發知, 淳子 Tokushima University
キーワード
Arterial stiffness
Augmentation index
Central blood pressure
Coronary artery disease
資料タイプ
学位論文
抄録
Background: Augmentation index (AI) has been used as a clinical index of arterial stiffness and has been reported to be an independent predictor of cardiovascular events, but some investigators have reported that AI is not a useful marker to identify coronary artery disease (CAD) in elderly patients. The majority of CAD patients are elderly people, therefore the aim of this study was to examine whether AI is a useful marker to identify the risk of CAD.
Methods and Results: A total of 120 patients (69±10 years of age; 83 male) who underwent cardiac catheterization for suspected CAD were enrolled. Invasive central blood pressure (BP) was measured using a fluid-filled catheter. Non-invasive AI was calculated by the SphygmoCor (AtCor Medical) system at the end of catheterization. Subjects consisted of 99 patients with CAD and 21 patients without CAD. There was no significant difference in AI between the CAD and the non-CAD groups (24±10 vs. 24±14%). Non-invasive systolic central BP was lower than the invasive systolic central BP (115±18 vs. 130±23 mmHg, P<0.001) in all patients. Non-invasive diastolic central BP was greater than the invasive diastolic central BP (67±10 vs. 63±10 mmHg, P<0.001).
Conclusions: In elderly patients, AI may not be a useful marker to identify CAD.
掲載誌名
Circulation Journal
ISSN
13474820
13469843
cat書誌ID
AA12022334
AA11591968
出版者
The Japanese Circulation Society
78
5
開始ページ
1176
終了ページ
1182
発行日
2014-02-24
備考
内容要旨・審査要旨・論文本文の公開
内容要旨・審査要旨 : LID201404221014.pdf
論文本文 : LID201407251001.pdf
訂正(Corrigendum) : LID201510281001.pdf
訂正(Corrigendum)の出版社版URL : https://doi.org/10.1253/circj.CJ-66-0120
本論文は, 著者Shuji Hayashiの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2670号
学位記番号
甲医第1194号
学位授与年月日
2014-03-24
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系