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ID 106036
著者
シマブクロ, ミチオ Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences|Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
小塚, 智沙代 Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
平良, 伸一郎 Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
屋比久, 浩市 Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
Dagvasumberel, Munkhbaatar Cardiovascular Division, Shonan Hospital
イシダ, マサヨシ Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
マツモト, サチコ Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
八木, 秀介 Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences 徳島大学 教育研究者総覧 KAKEN研究者をさがす
福田, 大受 Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences|Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ヤマカワ, ケン Diabetes and Lifestyle-Related Disease Center, Tomishiro Central Hospital
ヒガ, モリタケ Diabetes and Lifestyle-Related Disease Center, Tomishiro Central Hospital
添木, 武 Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ヨシダ, ヒサシ Cardiovascular Division, Shonan Hospital
益崎, 裕章 Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
佐田, 政隆 Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
obesity
insulin resistance
cardiovascular disease
diabetes mellitus
資料タイプ
学術雑誌論文
抄録
The obesity epidemic is a global public health concern that increases the likelihood of morbidity and mortality of metabolic and cardiovascular disease (CVD) and threatens to reduce life expectancy around the world. The concept of the metabolic syndrome (MetS) takes into account that visceral fat plays an essential role in the development of metabolic and cardiovascular diseases. However, MetS cannot be used to assess global CVD risk but is at best one more modifiable CVD risk factor. Thus, global cardiometabolic risk (the global risk of cardiovascular disease resulting from traditional risk factors combined with the additional contribution of the metabolic syndrome and/or insulin resistance) should be considered individually. There is solid evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as MetS. Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. Also, ectopic fat deposition could be deteriorated in the heart components such as (1) circulatory and locally recruited fat, (2) intra- and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is reviewed and also discussed are potential underlying mechanisms including adipocytokine, insulin resistance and lipotoxicity.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
60
1-2
開始ページ
1
終了ページ
14
並び順
1
発行日
2013-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系