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ID 111066
タイトル別表記
Regulation of Cell Cycle by Ubiquitin-mediated Proteolysis and Carcinogenesis Induced by Its Dysregulation
著者
キーワード
細胞周期
ユビキチン分解
プロテアソーム
資料タイプ
学術雑誌論文
抄録
In the process of carcinogenesis, abnormal regulation of cell cycle regulators is essential. Cell cycle is driven by the activity of Cyclin/Cyclin-dependent kinase (Cdk) complex. The activity of Cyclin/Cdk1 is regulated by the ubiquitin-proteasome pathway via controlling protein level of Cyclins. In addition to Cyclins, the protein level of various cell cycle regulators is strictly and precisely regulated by the ubiquitin-proteasome pathway. In particular, SCF (Skp1-Cullin-F-box) and anaphasepromoting complex/cyclosome (APC/C) ubiquitin ligase complex are involved in ubiquitylation of cell cycle regulators. It recently has been shown that overexpression of oncogenic cell cycle regulators and reduced expression of tumor suppressive cell cycle regulators are caused by abnormal regulation of ubiquitin-mediated proteolysis in cancer. In this review, we introduce abnormal regulation of cell cycle regulators in cancer.
掲載誌名
Journal of Oral Health and Biosciences
ISSN
21896682
出版者
四国歯学会
30
1
開始ページ
33
終了ページ
39
並び順
33
発行日
2017-06-30
出版社版DOI
出版社版URL
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
歯学系