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ID 109680
タイトル別表記
短時間の造影ダイナミック灌流画像を用いた脳腫瘍の質的診断について
著者
阿部, 考志 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧 KAKEN研究者をさがす
苛原, 早保 The University of Tokushima
Obama, Yuki The University of Tokushima
Majigsuren, Mungunkhuyag The University of Tokushima
Khashbat, Delgerdalai The University of Tokushima
影治, 照喜 The University of Tokushima KAKEN研究者をさがす
キーワード
Magnetic resonance imaging (MRI)
Dynamic contrast enhanced (DCE) perfusion
Brain tumor
Two-compartment model analysis
Pharmacokinetic model analysis
資料タイプ
学位論文
抄録
This study sought to determine the diagnostic utility of perfusion parameters derived from dynamic contrast-enhanced (DCE) perfusion MRI with a short acquisition time (approximately 3.5 min) in patients with glioma, brain metastasis, and primary CNS lymphoma (PCNSL).
Twenty-six patients with 29 lesions (4 low-grade glioma, 13 high-grade glioma, 7 metastasis, and 5 PCNSL) underwent DCE-MRI in a 3 T scanner. A ROI was placed on the hotspot of each tumor in maps for volume transfer contrast Ktrans, extravascular extracellular volume Ve, and fractional plasma volume Vp. We analyzed differences in parameters between tumors using the Mann–Whitney U test. We calculated sensitivity and specificity using receiver operating characteristics analysis.
Mean K trans values of LGG, HGG, metastasis and PCNSL were 0.034, 0.31, 0.38, 0.44, respectively. Mean Ve values of each tumors was 0.036, 0.57, 0.47, 0.96, and mean Vp value of each tumors was 0.070, 0.086, 0.26, 0.17, respectively. Compared with other tumor types, low-grade glioma showed lower Ktrans (P < 0.01, sensitivity = 88%, specificity = 100%) and lower Ve (P < 0.01, sensitivity = 96%, specificity = 100%). PCNSL showed higher Ve (P < 0.01, sensitivity = 100%, specificity = 88%), but the other perfusion parameters overlapped with those of different histology.
Kinetic parameters derived from DCE-MRI with short acquisition time provide useful information for the differential diagnosis of brain tumors.
掲載誌名
SpringerPlus
ISSN
21931801
出版者
Springer
4
開始ページ
88
発行日
2015-02-24
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606031003.pdf
論文本文 : LID201606031004.pdf
本論文は, 著者Takashi Abeの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
Copyright: © 2015 Abe et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2898号
学位記番号
甲医第1272号
学位授与年月日
2016-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院