ID 111884
著者
Aihara, Keisuke Tokushima University
Komiya, Chiaki Tokushima University
キーワード
Lactam-bridged peptide
Cyclic peptide
Ring-closing metathesis
Fmoc solid-phase peptide synthesis
Diimide reduction
資料タイプ
学術雑誌論文
抄録
A new approach has been developed for the synthesis of lactam-bridged cyclic peptides. Following the introduction of N-allyl glutamine and α-allylglycine into the peptide backbone, the side chains of these residues were subjected to a cyclization reaction by ring-closing metathesis (RCM). Reduction of the resulting peptide bearing olefin moiety was achieved using diimide, which was generated in situ from o-nitrobenzenesulfonyl hydrazine and piperidine, gave the corresponding saturated cyclic peptides.
掲載誌名
Tetrahedron
ISSN
00404020
cat書誌ID
AA00861787
AA11539786
出版者
Elsevier
71
24
開始ページ
4183
終了ページ
4191
発行日
2015-05-01
権利情報
© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系