Hayashi, Shigehito The University of Tokushima
Shibata, Hiroshi The University of Tokushima
The contrast medium-removing effect of hemofiltration (HF) and hemodiafiltration (HDF) was experimentally investigated using a bovine blood tank model. HF and HDF were performed at a blood flow rate of 100ml/min with a polysulfone hemofilter (PS filter-CF ; membrane area : 0.7 m2). Two hundred milliliters of iomeprol (300 mgI/ml) was administered by a single injection into 4 liters of bovine blood. The blood half-lives of iomeprol were 1.0 hr for the high flow rate HDF group [replacement fluid flow rate (QF) : 10 ml/min and dialysate flow rate (QD) : 40 ml/min], 1.8 hr for the HDF group (QF : 10 ml/min and QD : 10 ml/min), and 3.8 hr for the HF group (QF : 10 ml/min). The mean clearance rates were 39.7 ml/min for the high flow rate HDF group, 21.4 ml/min for the HDF group, and 12.0 ml/min for the HF group. Iomeprol was mostly excreted in the waste fluid. It is concluded that HDF can remove contrast media more effectively than HF.
The Journal of Medical Investigation
The University of Tokushima School of Medicine
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