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ID 116994
タイトル別表記
造影剤濃度と緩和能の定量的パラメータマッピングと脳腫瘍細胞外pH
著者
松元, 友暉 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧
Taniguchi, Yo FUJIFILM Healthcare Corporation
Ono, Masaharu FUJIFILM Healthcare Corporation
Bito, Yoshitaka FUJIFILM Healthcare Corporation
キーワード
MRI
QPM
pHe
pH
細胞外pH
資料タイプ
学位論文
抄録
In clinical magnetic resonance imaging, gadolinium-based contrast agents are commonly used for detecting brain tumors and evaluating the extent of malignancy. We present a new method to evaluate relaxivity (r1) and contrast agent concentration separately in contrast-enhanced lesions using quantitative parameter mapping (QPM). Furthermore, we also aimed to estimate the extracellular pH (pHe) of tumor lesions. We demonstrated that it is possible to evaluate pathophysiological tumor changes due to therapeutic efficacy by measuring r1 in contrast-enhanced lesions. In this study, the primary brain tumor group showed significantly higher r1 values than other brain disease groups (P < 0.001). Moreover, mean pHe value showed a trend for tumor malignancy having a lower pHe value and primary brain tumor having a significantly lower pHe than other brain diseases (P < 0.001). Our results might suggest that QPM can separately quantify r1 and CA concentration in brain tumors and that pHe brain tumor mapping could serve as a tumor biomarker. In conclusion, our method has potential clinical applications for assessing the treatment effects.
掲載誌名
Scientific Reports
ISSN
20452322
出版者
Springer Nature
12
開始ページ
2171
発行日
2022-02-09
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuki Matsumotoの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3599号
学位記番号
甲医第1532号
学位授与年月日
2022-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系