アクセス数 : ?
ダウンロード数 : ?
ID 111295
著者
Kishi, Kazuhiro Kagawa Prefectural Shirotori Hospital
Fujisawa, Akihiko Kagawa Prefectural Shirotori Hospital
Horikita, Minoru Kagawa Prefectural Shirotori Hospital
Nakai, Yoshihiro Kagawa Prefectural Shirotori Hospital
Ooshimo, Kazushi Kagawa Prefectural Shirotori Hospital
Kishi, Fumiko Tokushima University
木村, 雅子 Tokushima University
Lin, Chun-che Kagawa University
キーワード
NET
neuroendocrine carcinoma
gastric carcinoma
CD56
synaptophysin
資料タイプ
学術雑誌論文
抄録
Gastric neuroendocrine tumor (NET) is sometimes found as a submucosal tumor on upper gastrointestinal endoscopy. Gastric NET with malignant profile and neuroendocrine carcinoma (NEC) show various forms which are difficult to distinguish from gastric cancer and other disease. We report a case of a cauliflower-shaped NET of the stomach. A 61-year-old man was referred to our hospital with a complaint of abdominal fullness. Upper gastrointestinal endoscopic examination revealed an unusual, whitish cauliflower-shaped tumor that belongs to Borrmann type I on the lesser curvature of the gastric antrum. Histological examination of the biopsy specimen revealed NET G2, because the tumor cells were CD56- and synaptophysin-positive by immunohistochemical analysis. A distal gastrectomy with D2 lymphadenectomy was performed. A recurrence in the liver was revealed by follow up computed tomography after 11 months from operation. Combined chemotherapy with irinotecan (CPT-11) plus cisplatin (CDDP) was treated. The patient achieved a partial response, but he died after 31 months from gastrectomy. There is no independent, large-scaled prospective study and no standard treatment for gastric NETs with distant metastases. Our case is reported with a literature review of the treatment of metastatic gastric NET G2.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
62
3-4
開始ページ
251
終了ページ
257
並び順
251
発行日
2015-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系