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雌ラットにおいて生殖腺の状態とエストロゲン環境が視床下部オキシトシン遺伝子発現および血清オキシトシンレベルに及ぼす影響
著者
德井, 貴子 徳島大学大学院医科学教育部(医学専攻)
Yanagihara, Rie Tokushima University
湊, 沙希 Tokushima University
Takeda, Asuka Tokushima University
今泉, 絢貴 Tokushima University
キーワード
Oxytocin
Oxytocin receptor
Hypothalamus
Estradiol
Ovariectomy
資料タイプ
学位論文
抄録
Oxytocin (OT) and its receptor (OTR) play various roles in the central and peripheral regulation of appetite and body weight. Previously, we have shown that the administration of OT markedly decreased appetite and body weight gain in ovariectomized (OVX) obese rats. In addition, recent studies have shown that the endogenous OT system is also affected by endogenous or exogenous estrogen. In this study, we showed that ovariectomy decreased rats' hypothalamic OT/OTR mRNA and serum OT levels, but did not affect their visceral fat OTR mRNA levels. The chronic administration of estradiol (E2) abrogated these ovariectomy-induced changes; i.e., it increased the rats' hypothalamic OT/OTR mRNA and serum OT levels, and may be associated with reductions in food intake and body weight gain. In addition, acute E2 administration increased the rats' hypothalamic OTR mRNA and serum OT levels, but did not affect their hypothalamic OT mRNA levels. Taken together, these results suggest that endogenous OT and/or OTR expression might be positively regulated by E2 and that the suppressive effects of E2 on appetite and body weight gain might be mediated, at least in part, by the OT system. Thus, we consider that OT might be a target hormone to pursue subsequent interventions of menopause for menopause-induced metabolic disorders.
掲載誌名
Hormones and Behavior
ISSN
0018506X
cat書誌ID
AA00665370
AA11539414
出版者
Elsevier
133
開始ページ
105005
発行日
2021-06-08
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Takako Tokuiの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
© 2021 Elsevier Inc.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3592号
学位記番号
甲医第1521号
学位授与年月日
2022-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系