Difference between genders with metabolic syndrome
曽我部, 正弘 Tokushima University|Kagawa Prefectural Cancer Detection Center 徳島大学 教育研究者総覧 KAKEN研究者をさがす
岡久, 稔也 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Nakasono, Masahiko Tsurugi Municipal Handa Hospital
Fukuno, Hiroshi Higashi Tokushima Medical Center
Miyamoto, Yoshihiko Tokushima University
岡田, 泰行 Tokushima University 徳島大学 教育研究者総覧
岡崎, 潤 Tokushima University
三好, 人正 Tokushima University
友成, 哲 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
谷口, 達哉 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
郷司, 敬洋 Tokushima University KAKEN研究者をさがす
北村, 晋志 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
宮本, 弘志 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
六車, 直樹 Tokushima University KAKEN研究者をさがす
高山, 哲治 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Nonalcoholic fatty liver disease (NAFLD) is known to be strongly associated with obesity, visceral fat, metabolic syndrome (MS), lifestyle, and lifestyle-related diseases in both males and females. However, the prevalence of NAFLD, MS, and clinical backgrounds is different between males and females.
We conducted a cross-sectional study to examine the differing influence of lifestyle-related factors and visceral fat on fatty liver (FL) with elevation of liver enzymes between males and females with MS.
We enrolled 42,134 persons who underwent a regular health check-up, and after excluding subjects who fulfilled excluding criteria, the remaining subjects were 2,110 persons with MS. We examined the differing influence of lifestyle-related factors and visceral fat on FL with elevation of alanine aminotransferase (ALT) (ALT elevation was defined as ALT level of ≥31 IU/l in the present study).
The odds rations for FL with ALT elevation were as follows: WC, 1.83 (95% confidence interval (CI) 1.36-2.46); dyslipidemia, 1.89 (95% CI 1.34-2.68); hemoglobin A1c, 1.36 (95% CI 1.00-1.85); visceral fat type MS (V-type MS), 5.78 (95% CI 4.29-7.80); and light drinker, 0.56 (95% CI 0.41±0.78) in males with MS and BMI, 2.18 (95% CI 1.43－3.33); WC, 1.85 (95% CI 1.27-2.70); diastolic blood pressure, 1.69 (95% CI 1.16-2.45); triglyceride, 2.22 (95% CI 1.56-3.17); impaired glucose tolerance, 1.66 (95% CI 1.11-2.47); and V-type MS, 3.83 (95% CI 2.57-5.70) in females with MS. The prevalence of FL with ALT elevation and ALT was significantly higher in V-type MS than in the subcutaneous fat type MS in both males and females with MS (P < 0.001).
Although V-type MS and WC is a common significant predictor of an increased prevalence of FL with ALT elevation in both males and females with MS, gender, lifestyle-related factors, and MS type in individuals with MS should be considered for the development of FL with ALT elevation.
Copyright: © 2017 Sogabe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
pone_12_6_e0177925.pdf 583 KB