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ID 114370
著者
Nagasato, Daisuke Saneikai Tsukazaki Hospital|Hiroshima University
Akaiwa, Kei Tokushima University
長澤, 利彦 Saneikai Tsukazaki Hospital|Hiroshima University
Yoshizumi, Yuki Saneikai Tsukazaki Hospital
Tabuchi, Hitoshi Saneikai Tsukazaki Hospital
Kiuchi, Yoshiaki Hiroshima University
キーワード
Anti-vascular endothelial growth factor agent
Central retinal vein occlusion
Fundus-related microperimetry
Laser speckle flowgraphy
Retinal blood flow
資料タイプ
学術雑誌論文
抄録
Background: To determine the correlation between the optic nerve head (ONH) circulation determined by laser speckle flowgraphy and the best-corrected visual acuity or retinal sensitivity before and after intravitreal bevacizumab or ranibizumab for central retinal vein occlusion.
Methods: Thirty-one eyes of 31 patients were treated with intravitreal bevacizumab or ranibizumab for macular edema due to a central retinal vein occlusion. The blood flow in the large vessels on the ONH, the best-corrected visual acuity, and retinal sensitivity were measured at the baseline, and at 1, 3, and 6 months after treatment. The arteriovenous passage time on fluorescein angiography was determined. The venous tortuosity index was calculated on color fundus photograph by dividing the length of the tortuous retinal vein by the chord length of the same segment. The blood flow was represented by the mean blur rate (MBR) determined by laser speckle flowgraphy. To exclude the influence of systemic circulation and blood flow in the ONH tissue, the corrected MBR was calculated as MBR of ONH vessel area – MBR of ONH tissue area in the affected eye divided by the vascular MBR – tissue MBR in the unaffected eye. Pearson’s correlation tests were used to determine the significance of correlations between the MBR and the best-corrected visual acuity, retinal sensitivity, arteriovenous passage time, or venous tortuosity index.
Results: At the baseline, the corrected MBR was significantly correlated with the arteriovenous passage time and venous tortuosity index (r = -0.807, P < 0.001; r = -0.716, P < 0.001; respectively). The corrected MBR was significantly correlated with the best-corrected visual acuity and retinal sensitivity at the baseline, and at 1, 3, and 6 months (all P < 0.050). The corrected MBR at the baseline was significantly correlated with the best-corrected visual acuity at 6 months (r = -0.651, P < 0.001) and retinal sensitivity at 6 months (r = 0.485, P = 0.005).
Conclusions: The pre-treatment blood flow velocity of ONH can be used as a predictive factor for the best-corrected visual acuity and retinal sensitivity after anti-VEGF therapy for central retinal vein occlusion.
Trial registration: Trial Registration number: UMIN000009072. Date of registration: 10/15/2012.
掲載誌名
BMC Ophthalmology
ISSN
14712415
cat書誌ID
AA12035369
出版者
Springer Nature|BioMed Central
16
開始ページ
36
発行日
2016-04-05
備考
Trial registration: Trial Registration number: UMIN000009072 ( https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000010647 ). Date of registration: 10/15/2012.
権利情報
© 2016 Nagasato et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院