ID 83934
著者
クリタ, ノブヒロ Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
島田, 光生 Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
岩田, 貴 Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ニシオカ, マサノリ Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School
モリモト, シンヤ Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School
吉川, 幸造 Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
東島, 潤 Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ミヤタニ, トモヒコ Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
ナカオ, トシヒロ Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
キーワード
In intraperitoneal infusion of PTX with S-1
DLT was leukocytopenia
MTD and RD were PTX 90 mg/m2, 80 mg/m2, respectively.
These findings were supported by pharmocokinetics of PTX
資料タイプ
学術雑誌論文
抄録
Background : Intraperitoneal administration of taxanes revealed excellent anti-tumor effect for peritoneal metastasis of gastric cancer in some experimental models. The aim of this study is to determine maximum tolerated dose (MTD), dose limiting toxicity (DLT) and recommended dose (RD) of intraperitoneally infused paclitaxel (PTX) with S-1 as a phase I study. Patients and Methods : Eighteen patients with advanced gastric cancer in addition to confirmed peritoneal metastasis using laparoscopy were enrolled in this study. The regimen consists of oral administration of S-1 (Dose 80mg : BSA<1.25 m2, 100 mg : 1.25<BSA<1.5 m2, 120 mg : BSA>1.5 m2) for 14 days and intraperitoneal infusion of PTX (Dose escalation : level I : 40, II : 60, III : 80, level IV : 90, V : 100 mg/m2) at day1 and 14. PTX concentrations in serum and ascites were determined at 4, 8, 12, 24, 48 hours after the infusion, which was repeated twice every 4 weeks. Results : The number of patients were as follows : Level I : 3, Level II : 6, Level III : 3, Level IV : 3, Level V : 3. Grade 3 leukocytopenia was confirmed in 1 (Level II) and 2 (Level V). MTD is 90 mg/m2, RD is 80 mg/m2 and DLT is Grade 3 leukocytopenia. The average serum PTX concentrations remained in optimal range except for all 3 of level V patients. In all cohorts, the PTX concentrations in the ascites were approximately 1000 folds higher than those in serum for 48 hours after the infusion. Conclusions : MTD and RD were PTX 90 mg/m2, 80 mg/m2, respectively. These findings were supported by pharmocokinetics of PTX
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
58
1-2
開始ページ
134
終了ページ
139
並び順
134
発行日
2011-02
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
教養教育院
病院