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ダウンロード数 : ?
ID 106356
著者
タナカ, サラサ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
山本, 浩範 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Health and Nutrition, Faculty of Human Life, the Jin-ai University KAKEN研究者をさがす
中橋, 乙起 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
イシグロ, マリコ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
タケイ, ユウイチロウ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
増田, 真志 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
香西, 美奈 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
イケダ, ショウコ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
竹谷, 豊 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
宮本, 賢一 Department of Molecular Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
武田, 英二 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Npt2a
cholesterol
hyperlipidemia
hypophosphatemia
mice
資料タイプ
学術雑誌論文
抄録
The type IIa sodium-dependent phosphate co-transporter (Npt2a) is important to maintain renal inorganic phosphate (Pi) homeostasis and the plasma Pi levels. It has reported that disorder of Pi metabolism in kidney can be risk factors for cardiovascular disease as well as hypercholesterolemia. However, the relationship between Pi and cholesterol metabolism has not been clarified. The current study investigated the effects of Npt2a gene ablation that is known as hypophosphatemia model on cholesterol metabolism in mice. Npt2a deficient (Npt2a-/-) mice and wild type mice were fed diets with or without 2% cholesterol for 12 days. Plasma lipid and lipoprotein profile analysis revealed that plasma lipid levels (total, LDL and HDL cholesterol) were significantly higher in Npt2a-/- mice than wild type (WT) mice. Interestingly, high cholesterol diet markedly increased plasma levels of total, LDL and HDL cholesterol in WT mice, but not Npt2a-/- mice. On the other hand, there were no differences in body and liver weight, intake and hepatic lipid accumulation between WT and Npt2a-/- mice. These results suggest that ablation of Npt2a gene induces hypercholesterolemia and affects the ability to respond normally to dietary cholesterol.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
60
3-4
開始ページ
191
終了ページ
196
並び順
191
発行日
2013-08
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
先端酵素学研究所