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ID 114720
タイトル別表記
stearoyl-CoA desaturaseの低下は慢性腎臓病における過剰な小胞体ストレスを介して筋萎縮に寄与する
著者
新井田, 裕樹 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
Adachi, Yuichiro Tokushima University
Yoshizawa, Aika Tokushima University
Mori, Yuki Tokushima University
山本, 浩範 Tokushima University|Jin-ai University|University of Fukui KAKEN研究者をさがす
Miyazaki, Makoto University of Colorado Denver
キーワード
skeletal muscle atrophy
endoplasmic reticulum (ER) stress
chronic kidney disease (CKD)
stearoyl-CoA desaturase (SCD)
saturated fatty acid (SFA)
資料タイプ
学位論文
抄録
Skeletal muscle atrophy is associated with mortality and poor prognosis in patients with chronic kidney disease (CKD). However, underlying mechanism by which CKD causes muscle atrophy has not been completely understood. The quality of lipids (lipoquality), which is defined as the functional features of diverse lipid species, has recently been recognized as the pathology of various diseases. In this study, we investigated the roles of the stearoyl-CoA desaturase (SCD), which catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, in skeletal muscle on muscle atrophy in CKD model animals. In comparison to control rats, CKD rats decreased the SCD activity and its gene expression in atrophic gastrocnemius muscle. Next, oleic acid blocked the reduction of the thickness of C2C12 myotubes and the increase of the endoplasmic reticulum stress induced by SCD inhibitor. Furthermore, endoplasmic reticulum stress inhibitor ameliorated CKD-induced muscle atrophy (the weakness of grip strength and the decrease of muscle fiber size of gastrocnemius muscle) in mice and the reduction of the thickness of C2C12 myotubes by SCD inhibitor. These results suggest that the repression of SCD activity causes muscle atrophy through excessive endoplasmic reticulum stress in CKD.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
09120009
18805086
cat書誌ID
AA10710201
出版者
Society for Free Radical Research Japan
67
2
開始ページ
179
終了ページ
187
発行日
2020-09-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuki Niidaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
© 2020 Society for Free Radical Research Japan
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3419号
学位記番号
甲栄第280号
学位授与年月日
2020-03-23
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系