ID 113371
タイトル別表記
多層カーボンナノチューブの吸入曝露による線維化誘導型肺胞マクロファージへの長期変化
Effect of CNT exposure on alveolar macrophages
著者
大塚, 邦紘 徳島大学大学院口腔科学教育部(口腔科学専攻)
Yamada, Koichi Tokushima University
Taquahashi, Yuhji National Institute of Health Sciences
Kanno, Jun Japan Organization of Occupational Health and Safety
キーワード
Carbon nanotube
Taquann methods
alveolar macrophage
fibrosis
lung
資料タイプ
学位論文
抄録
Background
Nanomaterials are widely used in various fields. Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated, the toxicological effect of CNTs on the immune system in the lung remains unclear.
Methods and finding
In this study, exposure to Taquann-treated multi-walled CNTs (T-CNTs) was performed using aerosols generated in an inhalation chamber. At 12 months after T-CNT exposure, alveolar inflammation with macrophage accumulation and hypertrophy of the alveolar walls were observed. In addition, fibrotic lesions were enhanced by T-CNT exposure. The macrophages in the bronchoalveolar lavage fluid of T-CNT-exposed mice were not largely shifted to any particular population, and were a mixed phenotype with M1 and M2 polarization. Moreover, the alveolar macrophages of T-CNT-exposed mice produced matrix metalloprotinase-12.
Conclusions
These results suggest that T-CNT exposure promoted chronic inflammation and fibrotic lesion formation in profibrotic macrophages for prolonged periods.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
13
10
開始ページ
e0205702
発行日
2018-10-29
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Kunihiro Otsukaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
© 2018 Otsuka et al.
This is an open access article distributed under the terms of the Creative Commons Attribution License( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3281号
学位記番号
甲口第446号
学位授与年月日
2019-03-22
学位名
博士(歯学)
学位授与機関
徳島大学
部局
歯学系
医学系