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ID 114870
タイトル別表記
Age-related changes in a patient with Pelizaeus-Merzbacher disease by repeated 1H-MRS
著者
伊藤, 弘道 The University of Tokushima KAKEN研究者をさがす
Miyazaki, Masahito The University of Tokushima
Kurosawa, Kenji Kanagawa Children's Medical Center
資料タイプ
学術雑誌論文
抄録
Purpose:
In this report, we describe a patient with Pelizaeus-Merzbacher disease (PMD) who underwent repeated evaluations by 1H-Magnetic resonance spectroscopy (MRS).
Subject:
The patient was given a definitive diagnosis of PMD based on genetic testing, which showed overlap of the proteolipid protein 1 (PLP1) gene. The control subjects for 1H-MRS consisted of healthy age-matched children.
Methods:
All measurements were performed with a clinical 3-tesla magnetic resonance imaging (MRI) system. For 1H-MRS, the center of a voxel was positioned in the right parietal lobe. 1H-MRS was performed when the patient was 2, 6, 14, and 25 months old.
Results:
The concentration of GABA in early childhood (2 months 1.72 mM, 6 months 2.15 mM) was increased compared with that in normal controls. However, his GABA concentration was normalized at 14 and 25 months. The concentrations of Ins were increased after 6 months. No remarkable changes were seen in the concentration of Cho at any time.
Conclusion
These results suggest that the changes in metabolite concentrations during growth may reflect the pathological state of PMD. Furthermore, the lack of a change in the Cho concentration may be useful for differentiating PMD from other demyelinating diseases.
掲載誌名
Journal of Child Neurology
ISSN
08830738
17088283
cat書誌ID
AA10688598
AA12910008
出版者
SAGE Publications
29
2
開始ページ
283
終了ページ
288
発行日
2013-09-20
権利情報
Tatsuo Mori, Kenji Mori, Hiromichi Ito, Aya Goji, Masahito Miyazaki, Masafumi Harada, Kenji Kurosawa, Shoji Kagami, Age-Related Changes in a Patient With Pelizaeus-Merzbacher Disease Determined by Repeated 1H-Magnetic Resonance Spectroscopy, Journal of Child Neurology Volume: 29 issue: 2) pp. 283-288. Copyright © 2013 SAGE Publications. DOI: 10.1177/0883073813499635.
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出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
病院
医学系