ID 113579
タイトル別表記
Selective Effects of Emi1 Depletion in Cancer
著者
Shimizu, Natsumi Hiroshima University|Kinki University
Izumi Nakajima, Nakako National Institute of Radiological Sciences
Ogawa, Ikuko Hiroshima University
Kawai, Hidehiko Hiroshima University
Hirayama, Ryoichi National Institute of Radiological Sciences
Fujimori, Akira National Institute of Radiological Sciences
Okayasu, Ryuichi National Institute of Radiological Sciences
高田, 隆 Hiroshima University
工藤, 保誠 Hiroshima University|The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
資料タイプ
学術雑誌論文
抄録
Background: To improve the effectiveness of chemo- and radiotherapy only in cancer tissue is important for avoiding side effects.
Results: Emi1 depletion enhanced the sensitivity of anticancer reagents and X-ray irradiation in cancer cells.
Conclusion: Emi1 siRNA would be a useful new modality for enhancing the effect of chemo- and radiotherapy in various tumors.
Significance: This work provides new insights regarding synergistic effect of Emi1 knockdown in combination therapies.
掲載誌名
Journal of Biological Chemistry
ISSN
1083351X
cat書誌ID
AA1202441X
出版者
The American Society for Biochemistry and Molecular Biology
288
24
開始ページ
17238
終了ページ
17252
発行日
2013-05-03
備考
This research was originally published in the Journal of Biological Chemistry. Natsumi Shimizu, Nakako Izumi Nakajima, Takaaki Tsunematsu, Ikuko Ogawa, Hidehiko Kawai, Ryoichi Hirayama, Akira Fujimori, Akiko Yamada, Ryuichi Okayasu, Naozumi Ishimaru, Takashi Takata and Yasusei Kudo. Selective Enhancing Effect of Early Mitotic Inhibitor 1 (Emi1) Depletion on the Sensitivity of Doxorubicin or X-ray Treatment in Human Cancer Cells. J. Biol. Chem. 2013; Vol:288(24) pp.17238-17252.
権利情報
© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
歯学系