Selective Enhancing Effect of Early Mitotic Inhibitor 1 (Emi1) Depletion on the Sensitivity of Doxorubicin or X-ray Treatment in Human Cancer Cells

Shimizu, Natsumi; Izumi Nakajima, Nakako; Tsunematsu, Takaaki; Ogawa, Ikuko; Kawai, Hidehiko; Hirayama, Ryoichi; Fujimori, Akira; Yamada, Akiko; Okayasu, Ryuichi; Ishimaru, Naozumi; Takata, Takashi; Kudo, Yasusei

doi:10.1074/jbc.M112.446351

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ID	113579
タイトル別表記	Selective Effects of Emi1 Depletion in Cancer
著者	Shimizu, Natsumi Hiroshima University\|Kinki University Izumi Nakajima, Nakako National Institute of Radiological Sciences 常松, 貴明 Hiroshima University 徳島大学教育研究者総覧 KAKEN研究者をさがす Ogawa, Ikuko Hiroshima University Kawai, Hidehiko Hiroshima University Hirayama, Ryoichi National Institute of Radiological Sciences Fujimori, Akira National Institute of Radiological Sciences 山田, 安希子 The University of Tokushima KAKEN研究者をさがす Okayasu, Ryuichi National Institute of Radiological Sciences 石丸, 直澄 The University of Tokushima 徳島大学教育研究者総覧 KAKEN研究者をさがす高田, 隆 Hiroshima University 工藤, 保誠 Hiroshima University\|The University of Tokushima 徳島大学教育研究者総覧 KAKEN研究者をさがす
資料タイプ	学術雑誌論文
抄録	Background: To improve the effectiveness of chemo- and radiotherapy only in cancer tissue is important for avoiding side effects. Results: Emi1 depletion enhanced the sensitivity of anticancer reagents and X-ray irradiation in cancer cells. Conclusion: Emi1 siRNA would be a useful new modality for enhancing the effect of chemo- and radiotherapy in various tumors. Significance: This work provides new insights regarding synergistic effect of Emi1 knockdown in combination therapies.
掲載誌名	Journal of Biological Chemistry
ISSN	1083351X
cat書誌ID	AA1202441X
出版者	The American Society for Biochemistry and Molecular Biology
巻	288
号	24
開始ページ	17238
終了ページ	17252
発行日	2013-05-03
備考	This research was originally published in the Journal of Biological Chemistry. Natsumi Shimizu, Nakako Izumi Nakajima, Takaaki Tsunematsu, Ikuko Ogawa, Hidehiko Kawai, Ryoichi Hirayama, Akira Fujimori, Akiko Yamada, Ryuichi Okayasu, Naozumi Ishimaru, Takashi Takata and Yasusei Kudo. Selective Enhancing Effect of Early Mitotic Inhibitor 1 (Emi1) Depletion on the Sensitivity of Doxorubicin or X-ray Treatment in Human Cancer Cells. J. Biol. Chem. 2013; Vol:288(24) pp.17238-17252.
権利情報	© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
EDB ID	262412
出版社版DOI	10.1074/jbc.M112.446351
出版社版URL	https://doi.org/10.1074/jbc.M112.446351
フルテキストファイル	jbc_288_24_17238.pdf 4.5 MB
言語	eng
著者版フラグ	出版社版
部局	医学系歯学系