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ID 113582
タイトル別表記
Periostin Promotes Tumor Lymphangiogenesis
著者
工藤, 保誠 Hiroshima University|The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Iizuka, Shinji Hiroshima University
Yoshida, Maki Hiroshima University
Nguyen, Phuong Thao Hiroshima University
Siriwardena, Samadarani B. S. M. Hiroshima University
Ohbayashi, Mariko Hiroshima University
Ando, Toshinori Hiroshima University
Hatakeyama, Daijiro Gifu University
Shibata, Toshiyuki Gifu University
Koizumi, Keiichi University of Toyama
Maeda, Masahiro Immuno-Biological Laboratories
Ogawa, Ikuko Hiroshima University
高田, 隆 Hiroshima University
資料タイプ
学術雑誌論文
抄録
Background: Metastasis to regional lymph nodes via lymphatic vessels plays a key role in cancer progression. Tumor lymphangiogenesis is known to promote lymphatic metastasis, and vascular endothelial growth factor C (VEGF-C) is a critical activator of tumor lymphangiogenesis during the process of metastasis. We previously identified periostin as an invasion- and angiogenesis-promoting factor in head and neck squamous cell carcinoma (HNSCC). In this study, we discovered a novel role for periostin in tumor lymphangiogenesis.

Methods and Findings: Periostin overexpression upregulated VEGF-C mRNA expression in HNSCC cells. By using conditioned media from periostin-overexpressing HNSCC cells, we examined tube formation of lymphatic endothelial cells. Conditioned media from periostin-overexpressing cells promoted tube formation. To know the correlation between periostin and VEGF-C, we compared Periostin expression with VEGF-C expression in 54 HNSCC cases by immunohistochemistry. Periostin expression was correlated well with VEGF-C expression in HNSCC cases. Moreover, correlation between periostin and VEGF-C secretion was observed in serum from HNSCC patients. Interestingly, periostin itself promoted tube formation of lymphatic endothelial cells independently of VEGF-C. Periostin-promoted lymphangiogenesis was mediated by Src and Akt activity. Indeed possible correlation between periostin and lymphatic status in periostin-overexpressing xenograft tumors and HNSCC cases was observed.

Conclusions: Our findings suggest that periostin itself as well as periostin-induced upregulation of VEGF-C may promote lymphangiogenesis. We suggest that periostin may be a marker for prediction of malignant behaviors in HNSCC and a potential target for future therapeutic intervention to obstruct tumoral lymphatic invasion and lymphangiogenesis in HNSCC patients.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
7
8
開始ページ
e44488
発行日
2012-08-30
権利情報
© 2012 Kudo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
医学系