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ID 117463
著者
Sato, Mami Tokushima University
Tawara, Hiroaki Tokushima University
キーワード
NOD mice
autoimmune lesion
Sjögren’s syndrome
type 1 diabetes
antibiotic treatment
資料タイプ
学術雑誌論文
抄録
The relationship between autoimmunity and changes in intestinal microbiota is not yet fully understood. In this study, the role of intestinal microbiota in the onset and progression of autoimmune lesions in non-obese diabetic (NOD) mice was evaluated by administering antibiotics to alter their intestinal microenvironment. Flow cytometric analysis of spleen cells showed that antibiotic administration did not change the proportion or number of T and B cells in NOD mice, and pathological analysis demonstrated that autoimmune lesions in the salivary glands and in the pancreas were also not affected by antibiotic administration. These results suggest that the onset and progression of autoimmunity may be independent of enteral microbiota changes. Our findings may be useful for determining the appropriate use of antibiotics in patients with autoimmune diseases who are prescribed drugs to maintain systemic immune function.
掲載誌名
International Journal of Molecular Sciences
ISSN
14220067
出版者
MDPI
22
6
開始ページ
3239
発行日
2021-03-22
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
医学系