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ID 112397
タイトル別表記
ヒドロコルチゾン投与は日本人心肺停止患者の生存率改善に関連する
著者
新村, 貴博 徳島大学大学院医科学教育部(医学専攻)
座間味, 義人 Tokushima University|Okayama University KAKEN研究者をさがす
Koyama, Toshihiro Okayama University
Miyake, Masashi Okayama University
Koga, Tadashi Shin Nippon Biomedical Laboratories, Ltd
Harada, Keisaku Kitakyushu City Yahata Hospital
Ohshima, Ayako Okayama University
Imai, Toru Nihon University
Kondo, Yutaka Harvard Medical School
今西, 正樹 Tokushima University
武智, 研志 Tokushima University
堀ノ内, 裕也 Tokushima University
Hinotsu, Shiro Okayama University
Kano, Mitsunobu R. Okayama University
キーワード
Hydrocortisone
Cardiac arrest
Database
資料タイプ
学位論文
抄録
There are few reports on hydrocortisone administration after cardiac arrest, and those that have been published included few subjects. This study aimed to evaluate the effect of hydrocortisone administration on the outcomes of patients who experienced cardiac arrest. We investigated the survival discharge rates and the length of hospital stay from cardiac arrest to discharge, stratified by use of hydrocortisone, using a Japanese health-insurance claims dataset that covers approximately 2% of the Japanese population. The study included the data of 2233 subjects who experienced either in-hospital or out-of-hospital cardiac arrest between January 2005 and May 2014. These patients were divided into two groups, based on the administration of hydrocortisone. We adjusted the baseline characteristics, medical treatment, and drug administration data of the two groups using propensity scores obtained via the inverse probability of treatment weighted method. The hydrocortisone group had a significantly higher survival discharge rate (13/61 [21.1%] vs. 240/2172 [11.0%], adjusted odds ratio: 4.2, 95% CI: 1.60–10.98, p = 0.004). In addition, the administration of hydrocortisone was independent predictor of survival to discharge (hazard ratio: 4.6, p < 0.001). The results demonstrate a correlation between hydrocortisone administration and the high rates of survival to discharge.
掲載誌名
Scientific Reports
ISSN
20452322
出版者
Springer Nature
7
開始ページ
17919
発行日
2017-12-20
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Takahiro Niimuraの学位論文として提出され, 学位審査・授与の対象となっている。

Supplementary table : srep_7_17919_s1.doc
権利情報
© The Author(s) 2017
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EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3502号
学位記番号
甲医第1488号
学位授与年月日
2021-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院
薬学系