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ID 115332
タイトル別表記
マウスにおける動脈硬化性急性大動脈症候群の発症に対するケルセチンの予防効果
著者
近藤, 正輝 徳島大学大学院医科学教育部(医学専攻)
Hosooka, Mayuko Tokushima University
Kagimoto, Yuu Tokushima University
Saito, Naoko Tokushima University
Matsuoka, Rie Tokushima University
中馬, 真幸 Tokushima University
キーワード
quercetin
aortic aneurysm
aortic dissection
endothelial dysfunction
flavonoids
inflammation
資料タイプ
学位論文
抄録
Atherosclerosis-related acute aortic syndromes, such as aortic aneurysms or aortic dissection are life-threatening diseases. Since they develop suddenly and progress rapidly, the establishment of preventive strategies is urgently needed. Quercetin, a flavonoid abundant in various vegetables and fruits, is suggested to reduce the risk of cardiovascular disease. Therefore, in this study, the preventive effect of quercetin was evaluated using a mouse model of aortic aneurysm and dissection. The model was established by administering angiotensin II (Ang II) and β-aminopropionitrile (BAPN), a lysyl oxidase inhibitor, to mice to induce hypertension and degeneration of the elastic lamina, which would eventually result in the onset of an aortic aneurysm. Ang II, BAPN, and a nitric oxide synthase inhibitor was administered to induce aortic dissection via endothelial dysfunction. Quercetin (60 mg/kg/day) was administered 2 weeks before inducing aortic diseases by the end of the experiments (8 weeks in the aneurysm model, 6 weeks in the dissection model). It was found to reduce the incidence of aneurysm (from 72 to 45%), dissection (from 17 to 10%), and rupture (from 33 to 15%) in mice. Elastin degradation was ameliorated in the quercetin-treated mice compared to that in the mice without quercetin treatment (degradation score 2.9 ± 0.3 vs 2.2 ± 0.2). Furthermore, quercetin suppressed the expression of vascular cell adhesion molecule-1, macrophage infiltration, and pro-matrix metalloproteinase-9 activity. Our results suggest that quercetin might prevent the onset of atherosclerosis-related acute aortic syndromes through its anti-inflammatory and endothelial cell-protective effects.
掲載誌名
International Journal of Molecular Sciences
ISSN
14220067
16616596
出版者
MDPI
21
19
開始ページ
7226
発行日
2020-09-30
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Masateru Kondoの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3501号
学位記番号
甲医第1487号
学位授与年月日
2021-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院