ID | 115049 |
著者 |
Tanaka, Yu
NIH
近藤, 健太
NIH
Kondo, Hiroyuki
University of Tokushima
Palin, Amy C.
NIH
Hoffmann, Victoria
NIH
Uda, Shinsuke
Kyushu University
Motosugi, Ryo
The University of Tokyo
Hamazaki, Jun
The University of Tokyo
Kubota, Hiroyuki
Kyushu University
Murata, Shigeo
The University of Tokyo
Tanaka, Keiji
Tokyo Metropolitan Institute for Medical Science
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資料タイプ |
学術雑誌論文
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抄録 | The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have highlighted a rich diversity in functional mTEC subpopulations. Because of their limited cellularity, however, the biochemical characterization of TECs, including the proteomic profiling of cTECs and mTECs, has remained unestablished. Utilizing genetically modified mice that carry enlarged but functional thymuses, here we show a combination of proteomic and transcriptomic profiles for cTECs and mTECs, which identified signature molecules that characterize a developmental and functional contrast between cTECs and mTECs. Our results reveal a highly specific impact of the thymoproteasome on proteasome subunit composition in cTECs and provide an integrated trans-omics platform for further exploration of thymus biology.
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掲載誌名 |
Cell Reports
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ISSN | 22111247
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出版者 | Elsevier
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巻 | 29
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号 | 9
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開始ページ | 2901
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終了ページ | 2916
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発行日 | 2019-11-26
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権利情報 | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
先端酵素学研究所
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