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ID 111435
タイトル別表記
社会経済的格差のネガティブな認識と抑うつ気分は末梢血白血球のPPBPとSLC1A7 遺伝子の発現を低下させる
著者
藤田, 絹代 徳島大学大学院医科学教育部(医学専攻)
Saijo, Saki Tokushima University
西川, 達哉 Tokushima University
キーワード
subjective socioeconomic status
depressive mood
peripheral blood leukocytes
gene expression
PPBP
SLC1A7
資料タイプ
学位論文
抄録
Inequality in socioeconomic status (SES) is associated with an increased risk for the development of mental health problems. Here, we examined the association between socioeconomic status (SSS) and psychological distress, and measured gene expression signatures in peripheral blood leukocytes responsible for this association, in 129 healthy adults (27 males and 102 females, aged 44.0 ± 13.0 years) working in a private hospital in Japan. Depressive mood was assessed by Zung Selfrating Depression Scale (SDS). A multiple regression analysis adjusted for gender and age showed that subjective SSS was independently and negatively associated with SDS score. We next focused on 9 subjects who exhibited low SSS scores and 11 subjects with high SSS scores. Microarray analysis revealed that levels of 522 mRNAs were differentially expressed in periheral leukocytes between low and high-SSS groups. The differentially expressed genes were preferentially involved in cellular movement or inflammatory responses. Among them, mRNA levels of pro-platelet basic protein (PPBP) and solute carrier family 1 (glutamine transporter), member 7 (SLC1A7) were negatively correlated with SSS scores. Our results re-confirmed the association between negative perception of SES and depressive mood in healthy adults, and suggest a possible involvement of PPBP and SLC1A7 in the association.
掲載誌名
Cogent Psychology
ISSN
23311908
出版者
Cogent OA
4
開始ページ
1338825
発行日
2017-06-14
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Kinuyo Fujitaの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© 2017 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3129号
学位記番号
甲医第1363号
学位授与年月日
2018-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系