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ID 114022
タイトル別表記
2型糖尿病患者における終末糖化産物の蓄積とサルコペニアおよびダイナペニアとの関連
Dynapenia and AGEs in type 2 diabetes
著者
Ishizu, Masashi Tokushima University
Ohishi, Mami Tokushima University
髙士, 祐一 Tokushima University
Otsuka, Yinhua Tokushima University
Akehi, Yuko Tokushima University
キーワード
糖尿病
終末糖化産物
サルコペニア
ダイナペニア
Advanced glycation end-products
Dynapenia
Sarcopenia
資料タイプ
学位論文
抄録
Aims/Introduction: Advanced glycation end-products (AGEs), which are a major cause of diabetic vascular complications, accumulate in various tissues under chronic hyperglycemic conditions, as well as with aging in patients with diabetes. The loss of muscle mass and strength, so-called sarcopenia and dynapenia, has recently been recognized as a diabetic complication. However, the influence of accumulated AGEs on muscle mass and strength remains unclear. The present study aimed to evaluate the association of sarcopenia and dynapenia with accumulated AGEs in patients with type 2 diabetes.
Materials and Methods: We recruited 166 patients with type 2 diabetes aged ≥30 years (mean age 63.2 ± 12.3 years; body mass index 26.3 ± 4.9 kg/m2; glycated hemoglobin 7.1 ± 1.1%). Skin autofluorescence as a marker of AGEs, limb skeletal muscle mass index, grip strength, knee extension strength and gait speed were assessed.
Results: Sarcopenia and dynapenia were observed in 7.2 and 13.9% of participants, respectively. Skin autofluorescence was significantly higher in patients with sarcopenia and dynapenia. Skin autofluorescence was the independent determinant for skeletal muscle mass index, grip strength, knee extension strength, sarcopenia and dynapenia.
Conclusions: Accumulated AGEs could contribute to reduced muscle mass and strength, leading to sarcopenia and dynapenia in patients with type 2 diabetes.
掲載誌名
Journal of Diabetes Investigation
ISSN
20401124
出版者
Asian Association for the Study of Diabetes|John Wiley & Sons Australia
10
5
開始ページ
1332
終了ページ
1340
発行日
2019-01-24
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hiroyasu Moriの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
© 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License(https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
乙第2114号
学位記番号
乙医第1761号
学位授与年月日
2020-09-10
学位名
博士(医学)
学位授与機関
徳島大学
部局
先端酵素学研究所
病院
医学系