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ID 115936
タイトル別表記
食道扁平上皮癌患者の化学療法効果と予後予測に関わるバイオマーカー
著者
井上, 聖也 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧
古北, 由仁 Tokushima University
キーワード
biomarker
prognosis
chemo-resistance
predictive factor
esophageal squamous cell carcinoma
資料タイプ
学位論文
抄録
Background: The prognosis of patients with esophageal squamous cell carcinoma (ESCC) has been improved by multidisciplinary therapy with chemoradiotherapy and surgery, but it remains poor. Advanced stage, malignant potential, and chemo-resistance contribute to the poor prognosis. Here, we attempted to identify predictive factors of the response to chemotherapy and the prognosis of ESCC patients.
Patients and Methods: We examined 51 ESCC patients who were treated with chemotherapy followed by radical surgery, and 23 patients who were treated with chemotherapy alone. We conducted quantitative reverse transcription polymerase chain reaction gene expression analysis using RNA extracted from 74 tumor tissue samples collected before chemotherapy and 67 tumor tissue samples collected after chemotherapy, focusing on PIK3CA, AKT-1, mTOR, 4E-BP1, p70S6K, PD-L1, and PD-L2.
Results: The proportions of patients with high expressions of AKT-1 and PD-L1 before chemotherapy were significantly higher among the non-responders than among the responders (p=0.034, p=0.020, respectively). Multivariate analyses revealed that high PD-L1 expression before chemotherapy was associated with poor response to chemotherapy (odds ratio: 2.998; 95% CI: 1.043–8.619; p=0.042) and high p70S6K expression before chemotherapy was a poor prognostic factor (hazard ratio: 2.518; 95% CI: 1.058–5.988; p=0.037). In addition, the patients with high expression of PD-L1 and PD-L2 in the tumors after chemotherapy had significantly worse survival than those with low expression of these genes (p=0.012, p=0.007, respectively).
Conclusion: These results demonstrated that PD-L1 and p70S6K in the primary ESCC tissues were related to a poor response to chemotherapy and poor prognosis, respectively.
掲載誌名
General Thoracic and Cardiovascular Surgery
ISSN
18636705
18636713
cat書誌ID
AA12201344
出版者
The Japanese Association for Thoracic Surgery|Springer Nature
69
3
開始ページ
525
終了ページ
533
発行日
2021-01-15
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Seiya Inoueの学位論文として提出され,学位審査・授与の対象となっている。
This is a post-peer-review, pre-copyedit version of an article published in General Thoracic and Cardiovascular Surgery.
The final authenticated version is available online at: https://doi.org/10.1007/s11748-021-01586-5
論文本文は2022-01-15以降公開予定。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
jpn
著者版フラグ
その他
文科省報告番号
甲第3477号
学位記番号
甲医第1479号
学位授与年月日
2021-02-25
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院