Association of phase angle with muscle function and prognosis
Yamanaka, Ayaka Tokushima University
Furumoto, Taiki Tokushima University
Kubo, Miyu Tokushima University
Hayashi, Haruka Tokushima University
Kitao, Midori Tokushima University
Wada, Kyoko Tokushima University
Ohmae, Nao Tokushima University
島田, 亜紀 Tokushima University
Head and neck cancer
Objective: We aimed to investigate the correlation of phase angle (PhA) with other parameters (e.g., muscle mass/quality/strength and physical function), assess the prognostic relevance of pre-chemoradiotherapy (CRT) PhA, and suggest a reference value of PhA in Asian patients with head and neck cancer (HNC).
Research Methods & Procedures: Ninety-six patients with HNC who underwent CRT were divided into two groups, maintained-PhA group and low-PhA group, according to the PhA 25th percentile values by sex. Pretreatment PhA was measured using direct segmental multi-frequency bioelectrical impedance analysis, and muscle quality was assessed using echo intensity in ultrasound images. Correlation of PhA with other parameters was investigated, and between-group differences with respect to adverse events, treatment interruption, and 3-year survival were assessed.
Results: PhA showed a positive correlation with isometric knee extension force (R = 0.710), handgrip strength (R = 0.649), skeletal muscle mass index (R = 0.620), and maximum gait speed (R = 0.543) (P < 0.001). PhA showed a negative correlation with echo intensity (R = −0.439) and five times sit-to-stand test (R = −0.505) (P < 0.01). The low-PhA group had a higher incidence of severe anemia (52% in low-PhA vs. 17% in maintained-PhA), aspiration (17% vs. 1%), radiotherapy interruption (17% vs. 3%), and poor 3-year survival (47% vs. 81%) than the maintained-PhA group (P < 0.05).
Conclusion: PhA was correlated with muscle mass/quality/strength, and physical function. Low PhA was associated with severe adverse events, treatment interruption, and shorter survival. These findings suggested that 4.6° for men and 4.0° for women may be useful as prognostic reference values in Asian patients with HNC.
© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/