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ID 113741
タイトル別表記
The mechanism of skeletal muscle atrophy : finding from space experiment
著者
キーワード
Unloading stress
Muscle atrophy
Mitochondria
Reactive oxygen species
資料タイプ
学術雑誌論文
抄録
Skeletal muscle atrophy is a response to decreased physical signals (unloading), such as under microgravity, bed rest and neural inactivation, and is characterized by muscle volume loss and muscle fiber-type switching.
We previously demonstrated that elevated ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) resulted in the loss of muscle volume. Here, we showed that the ROS-mediated signal transduction caused by microgravity or its simulation contributes to Cbl-b expression.
In L6 myotubes, the assessment of redox status revealed that oxidized glutathione was increased under microgravity conditions, and simulated microgravity caused a burst of ROS, implicating ROS as a critical upstream mediator linking to downstream atrophic signaling. ROS generation activated the ERK 1/2 early-growth response protein (Egr) 1/2-Cbl-b signaling pathway.
Our results suggest that under microgravity conditions, elevated ROS may be a crucial mechanotransducer in skeletal muscle cells, regulating muscle mass through Cbl-b expression activated by the ERK-Egr signaling pathway.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
75
1-2
開始ページ
11
終了ページ
16
並び順
11
発行日
2019-04-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系