ID 112451
タイトル別表記
Effects of testosterone injection
著者
矢野, 清人 Tokushima University
Yanagihara, Rie Tokushima University
Mayila, Yiliyasi Tokushima University
キーワード
Testosterone
kisspeptin
RFRP
NKB
dynorphin
資料タイプ
学術雑誌論文
抄録
The effects of androgens on gonadotropin-releasing hormone (GnRH) secretion in females have not been fully established. To clarify the direct effects of androgens on hypothalamic reproductive factors, we evaluated the effects of chronic testosterone administration on hypothalamic GnRH regulatory factors in ovariectomized (OVX) female rats. Both testosterone and estradiol reduced the serum luteinizing hormone levels of OVX female rats, indicating that, as has been found for estrogen, testosterone suppresses GnRH secretion via negative feedback. Similarly, the administration of testosterone or estradiol suppressed the hypothalamic mRNA levels of kisspeptin and neurokinin B, both of which are positive regulators of GnRH, whereas it did not affect the hypothalamic mRNA levels of the kisspeptin receptor or neurokinin 3 receptor. On the contrary, the administration of testosterone, but not estradiol, suppressed the hypothalamic mRNA expression of prodynorphin, which is a negative regulator of GnRH. The administration of testosterone did not alter the rats’ serum estradiol levels, indicating that testosterone’s effects on hypothalamic factors might be induced by its androgenic activity. These findings suggest that as well as estrogen, androgens have negative feedback effects on GnRH in females and that the underlying mechanisms responsible for these effects are similar, but do not completely correspond, to the mechanisms underlying the effects of estrogen on GnRH.
掲載誌名
Gynecological Endocrinology
ISSN
09513590
14730766
cat書誌ID
AA10839977
出版者
Taylor & Francis
34
5
開始ページ
437
終了ページ
441
発行日
2017-11-29
備考
This is an Accepted Manuscript of an article published by Taylor & Francis in Gynecological Endocrinology on 29/11/2017, available online: http://www.tandfonline.com/10.1080/09513590.2017.1409709.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
病院
医学系