ID 112455
タイトル別表記
Effects of DHT injection
著者
矢野, 清人 Tokushima University
Mayila, Yiliyasi Tokushima University
キーワード
Dihydrotestosterone
estradiol
kisspeptin
GnIH
資料タイプ
学術雑誌論文
抄録
To clarify the direct effects of androgens, the changes in the hypothalamic levels of reproductive and appetite regulatory factors induced by chronic dihydrotestosterone (DHT) administration were evaluated in female rats. DHT treatment increased the BW and food intake of the ovariectomized rats, but not the estradiol (E2)-treated rats. DHT administration suppressed the expression of a hypothalamic anorexigenic factor. Although the kisspeptin (Kiss1) mRNA levels of the anterior hypothalamic block (the anteroventral periventricular nucleus, AVPV) were increased in the E2-treated rats, DHT administration did not affect the Kiss1 mRNA levels of the AVPV in the ovariectomized or E2-treated rats. Conversely, DHT administration reduced the Kiss1 mRNA levels of the posterior hypothalamic block (the arcuate nucleus, ARC) in the ovariectomized rats. Although the Kiss1 mRNA levels of the posterior hypothalamic block (ARC) were decreased in the E2-treated rats, DHT administration did not affect the Kiss1 mRNA levels of the ARC in these rats. Serum luteinizing hormone levels of these groups exhibited similar patterns to the Kiss1 mRNA levels of the ARC. These results showed that DHT affects the production of hypothalamic reproductive and appetite regulatory factors, and that these effects of DHT differ according to the estrogen milieu.
掲載誌名
Gynecological Endocrinology
ISSN
09513590
14730766
cat書誌ID
AA10839977
出版者
Taylor & Francis
34
1
開始ページ
73
終了ページ
77
発行日
2017-06-11
備考
This is an Accepted Manuscript of an article published by Taylor & Francis in Gynecological Endocrinology on 11/06/2017, available online: http://www.tandfonline.com/10.1080/09513590.2017.1337096.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
病院
医学系