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ID 118201
タイトル別表記
Muscle strength is a stronger prognostic factor than muscle mass in patients with gastrointestinal and hepatobiliary-pancreatic cancers
Muscle strength is a stronger prognostic factor than mass
著者
Nasu, Nanami Tokushima University
Kagiya, Natsumi Tokushima University
Takimoto, Mami Tokushima University
黒川, 有美子 Tokushima University
(谷)鈴木, 佳子 Tokushima University
キーワード
Skeletal muscle mass
Handgrip strength
Sarcopenia
Dynapenia
Survival
Gastrointestinal and hepatobiliary pancreatic cancer
gastrointestinal and hepatobiliary-pancreatic cancer
資料タイプ
学術雑誌論文
抄録
Objective: Sarcopenia have been reported as a prognostic risk factor in patients with gastrointestinal (GI) and hepatobiliary-pancreatic (HBP) cancers. This study aimed to investigate whether the loss of muscle mass or strength is a stronger prognostic factor and explore the cutoff values of skeletal muscle mass index (SMI) and handgrip strength (HGS) based on the survival outcome in patients with GI and HBP cancers.
Methods: A total of 480 elderly patients with primary GI and HBP cancers who underwent their first resection surgery were analyzed retrospectively. The patients were divided into four groups: appropriate SMI and HGS, low SMI alone, low HGS alone, and low SMI and HGS. Low SMI derived from a bioelectrical impedance analysis and low HGS were defined according to the Asian Working Group for Sarcopenia 2019 criteria.
Results: Multivariate analysis showed that the low SMI was a significant risk factor for mortality only in men, while the low HGS was significant in both sexes. From the multivariate analysis of the four groups, the low HGS alone and low SMI and HGS showed a significantly higher hazard ratio than appropriate SMI and HGS in both sexes. SMI 7.21 kg/m2 and HGS 28 kg were obtained as cutoff values based on the 3-year survival outcomes in men.
Conclusion: Low muscle strength was a stronger prognostic factor than low muscle mass. Therefore, it is essential to measure muscle strength in all the patients.
掲載誌名
Nutrition
ISSN
08999007
18731244
cat書誌ID
AA10745727
AA11535297
出版者
Elsevier
103-104
開始ページ
111826
発行日
2022-08-18
権利情報
© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
医学系
病院