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ID 114104
タイトル別表記
Vitamin B6 and schizophrenia
著者
キーワード
Schizophrenia
Vitamin B6
Pyridoxal
Mendelian randomization
One-carbon metabolism
Homocysteine
資料タイプ
学術雑誌論文
抄録
Accumulating evidence indicates that alterations in one-carbon metabolism may play an important role in the pathogenesis of schizophrenia. We focused on vitamin B6 (pyridoxal), which works as a coenzyme in one-carbon metabolism. We first conducted a case-control study and demonstrated that serum pyridoxal levels were significantly lower in the schizophrenia group than in the control group. Subsequently, we conducted a meta-analysis of case-control studies and achieved the similar result to the case-control study. Finally, we investigated the causality between serum pyridoxal levels and schizophrenia by a Mendelian randomization analysis. However, we could indicate no significant causality between serum pyridoxal levels and schizophrenia in the Japanese population. Further studies such as a longitudinal study will be needed because there are several studies on the benefits of vitamin B6 in schizophrenia.
掲載誌名
ビタミン
ISSN
0006386X
2424080X
cat書誌ID
AA11693298
出版者
日本ビタミン学会
92
10
開始ページ
450
終了ページ
456
発行日
2018-10-25
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
病院
医学系