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ID 115397
タイトル別表記
性別に基づく血清葉酸濃度と統合失調症との関連
Folate and sex in schizophrenia
Association between serum folate levels and schizophrenia based on gender
Folate and gender in schizophrenia
著者
富岡, 有紀子 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧
キーワード
統合失調症
葉酸
ホモシステイン
ビタミンB6
folate
homocysteine
pyridoxal
schizophrenia
vitamin B6
資料タイプ
学位論文
抄録
Aim: Gender differences in serum folate concentrations are well known, but no studies have investigated the association between serum folate levels and schizophrenia based on gender. In this study in a Japanese population, we examined the difference in serum folate levels between patients with schizophrenia and non‐psychiatric controls stratified by gender. The relationships between serum folate levels, plasma total homocysteine (tHcy) and serum vitamin B6 (pyridoxal) levels were also examined using data from our previous studies.
Methods: The serum folate concentrations of 482 patients diagnosed with schizophrenia and 1,350 non‐psychiatric control subjects were measured. We conducted an analysis of covariance to examine the differences in serum folate levels between the two groups based on gender. Spearman’s rank correlation was used to evaluate the relationships between folate, tHcy and vitamin B6 levels.
Results: In the control group, serum folate concentrations were higher in women than in men. Lower levels of serum folate were observed in both male and female patients with schizophrenia. An inverse correlation between serum folate and plasma tHcy and a weak positive correlation between serum folate and vitamin B6 were observed in the combined cohort.
Conclusion: Our findings suggest that (1) a low serum folate level may be associated with schizophrenia regardless of gender, and (2) folate administration may be beneficial for the treatment of schizophrenia. In schizophrenic patients with low serum folate levels, folate administration might result in improvements in high tHcy and an increase in low vitamin B6 levels.
掲載誌名
Psychiatry and Clinical Neurosciences
ISSN
13231316
14401819
cat書誌ID
AA11040669
出版者
Wiley|Japanese Society of Psychiatry and Neurology
74
9
開始ページ
466
終了ページ
471
発行日
2020-05-23
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yukiko Tomiokaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This is the peer reviewed version of the following article: Tomioka, Y., Kinoshita, M., Umehara, H., Nakayama, T., Watanabe, S.‐y., Nakataki, M., Numata, S. and Ohmori, T. (2020), Association between serum folate levels and schizophrenia based on sex. Psychiatry Clin. Neurosci., 74: 466-471, which has been published in final form at https://doi.org/10.1111/pcn.13074.
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3464号
学位記番号
甲医第1470号
学位授与年月日
2020-10-22
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系