直近一年間の累計
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ID 117414
著者
Kawashiri, Takehiro Kyushu University
Naito, Yutaro Tokushima University
Ushio, Soichiro Okayama University
Miyata, Koji Tokushima University
武智, 研志 Matsuyama University
中馬, 真幸 Asahikawa Medical University
Koyama, Toshihiro Okayama University
Kobayashi, Daisuke Kyushu University
Shimazoe, Takao Kyushu University
キーワード
Drug repositioning
Simvastatin
Oxaliplatin-induced peripheral neuropathy
Database
資料タイプ
学術雑誌論文
抄録
Background: Drug repositioning is a cost-effective method to identify novel disease indications for approved drugs; it requires a shorter developmental period than conventional drug discovery methods. We aimed to identify prophylactic drugs for oxaliplatin-induced peripheral neuropathy by drug repositioning using data from large-scale medical information and life science information databases.
Methods: Herein, we analyzed the reported data between 2007 and 2017 retrieved from the FDA’s database of spontaneous adverse event reports (FAERS) and the LINCS database provided by the National Institute of Health. The efficacy of the drug candidates for oxaliplatin-induced peripheral neuropathy obtained from the database analysis was examined using a rat model of peripheral neuropathy. Additionally, we compared the incidence of peripheral neuropathy in patients who received oxaliplatin at the Tokushima University Hospital, Japan. The effects of statins on the animal model were examined in six-week-old male Sprague–Dawley rats and seven or eight-week-old male BALB/C mice. Retrospective medical chart review included clinical data from Tokushima University Hospital from April 2009 to March 2018.
Results: Simvastatin, indicated for dyslipidemia, significantly reduced the severity of peripheral neuropathy and oxaliplatin-induced hyperalgesia. In the nerve tissue of model rats, the mRNA expression of Gstm1 increased with statin administration. A retrospective medical chart review using clinical data revealed that the incidence of peripheral neuropathy decreased with statin use.
Conclusion and relevance: Thus, drug repositioning using data from large-scale basic and clinical databases enables the discovery of new indications for approved drugs with a high probability of success.
掲載誌名
Biomedicine & Pharmacotherapy
ISSN
07533322
cat書誌ID
AA10506249
AA11523196
出版者
Elsevier
148
開始ページ
112744
発行日
2022-02-28
権利情報
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院
薬学系