ID | 116504 |
タイトル別表記 | グルタミン酸ナトリウムの食事への添加は健常女性のT1R3味覚受容体遺伝子発現の増加に伴いタンパク質、塩分、糖分摂取などのバランスの取れた食事をもたらす
monosodium glutamate increases T1R3 expression
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著者 |
Beppu, Kana
Tokushima University
Kawakami, Ayuka
Tokushima University
Takashi, Tomoe
Tokushima University
Watanabe, Suzuno
Tokushima University
Yoshida, Akari
Tokushima University
藤本, 知佐
Tokushima University
Ohnishi, Hiroki
Tokushima University
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キーワード | monosodium glutamate (MSG)
T1R3 genes
dietary balance
taste 1 receptor 3 (T1R3)
dysgeusia
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資料タイプ |
学位論文
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抄録 | We previously showed that chemotherapy-induced dysgeusia was associated with lingual taste receptor gene expression, and monosodium glutamate (MSG) improved dysgeusia by upregulating taste 1 receptor 3 (T1R3) gene expression. In recent years, decreased taste sensitivity has also been reported in some young people, and these are partly due to their disordered eating habits. From these background, we investigated the effects of MSG supplementation on taste receptor expression and dietary intake in healthy females. Fifteen young healthy volunteers were enrolled for the present crossover study and divided in two groups (dietary supplementation with MSG at 2.7 g / day or 0.27 g / day). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative PCR analysis. Food intake was assessed by food frequency questionnaire (FFQg), and body composition was measured using Omron HBF-701. T1R3 expression levels in the tongue and taste sensitivity increased significantly in participants who consumed <10 g of MSG daily, whereas no alteration was observed in participants who consumed >10 g of MSG daily. Furthermore, protein, fat, and carbohydrate (PFC) balance and salt and sugar intake improved by MSG supplementation. In conclusion, MSG supplementation increased T1R3 expression in the tongue and improved dietary balance.
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掲載誌名 |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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cat書誌ID | AA11166929
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出版者 | Tokushima University Faculty of Medicine
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巻 | 68
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号 | 3-4
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開始ページ | 315
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終了ページ | 320
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並び順 | 315
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発行日 | 2021-08
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Hitoshi Shonoの学位論文として提出され,学位審査・授与の対象となっている。 著者名英表記誤記あり (誤)Takahito Azuma→(正)Takahiro Azuma |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3589号
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学位記番号 | 甲医第1530号
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学位授与年月日 | 2022-03-16
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学位名 |
博士(医学)
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学位授与機関 |
徳島大学
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部局 |
医学系
病院
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