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ID 118430
著者
森谷, 眞紀 The University of Tokushima
Togawa, Katsuhiko The University of Tokushima|Otsuka Pharmaceutical, Inc.
Yaguchi, Hiroshi Otsuka Pharmaceutical Factory, Inc.
Fujita, Yuka The University of Tokushima
井上, 寛 The University of Tokushima
鎌谷, 直之 Tokyo Women's Medical University
キーワード
Type 2 diabetes (T2D)
Leprdb (db) mice
F2 intercross
R/qtl
Conditional QTL
SNP (single-nucleotide polymorphism)
Haplotype block
Haplotype mapping
資料タイプ
学術雑誌論文
抄録
To identify the disease-susceptibility genes of type 2 diabetes, we performed quantitative trait loci (QTL) analysis in F2 populations generated from a BKS.Cg-m+/+Leprdb and C3H/HeJ intercross, taking advantage of genetically determined obesity and diabetes traits associated with the db gene. A genome-wide scan in the F2 populations divided by sex and db genotypes identified 14 QTLs in total and 3 major QTLs on chromosome (Chr) 3 (LOD 5.78) for fat pad weight, Chr 15 (LOD 6.64) for body weight, and Chr 16 (LOD 8.15) for blood glucose concentrations. A linear-model-based genome scan using interactive covariates allowed us to consider sex- or sex-by db-specific effects of each locus. For the most significant QTL on Chr 16, the high-resolution haplotype comparison between BKS and C3H strains reduced the critical QTL interval from 20 to 4.6 Mb by excluding shared haplotype regions and identified 11 nonsynonymous single-nucleotide polymorphisms in six candidate genes.
掲載誌名
Genomics
ISSN
08887543
10898646
cat書誌ID
AA10678346
AA11537587
出版者
Elsevier
88
6
開始ページ
719
終了ページ
730
発行日
2006-08-17
権利情報
Open Archive
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
AWAサポートセンター
先端酵素学研究所