ID | 118430 |
著者 |
森谷, 眞紀
The University of Tokushima
Togawa, Katsuhiko
The University of Tokushima|Otsuka Pharmaceutical, Inc.
Yaguchi, Hiroshi
Otsuka Pharmaceutical Factory, Inc.
Fujita, Yuka
The University of Tokushima
井上, 寛
The University of Tokushima
鎌谷, 直之
Tokyo Women's Medical University
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キーワード | Type 2 diabetes (T2D)
Leprdb (db) mice
F2 intercross
R/qtl
Conditional QTL
SNP (single-nucleotide polymorphism)
Haplotype block
Haplotype mapping
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資料タイプ |
学術雑誌論文
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抄録 | To identify the disease-susceptibility genes of type 2 diabetes, we performed quantitative trait loci (QTL) analysis in F2 populations generated from a BKS.Cg-m+/+Leprdb and C3H/HeJ intercross, taking advantage of genetically determined obesity and diabetes traits associated with the db gene. A genome-wide scan in the F2 populations divided by sex and db genotypes identified 14 QTLs in total and 3 major QTLs on chromosome (Chr) 3 (LOD 5.78) for fat pad weight, Chr 15 (LOD 6.64) for body weight, and Chr 16 (LOD 8.15) for blood glucose concentrations. A linear-model-based genome scan using interactive covariates allowed us to consider sex- or sex-by db-specific effects of each locus. For the most significant QTL on Chr 16, the high-resolution haplotype comparison between BKS and C3H strains reduced the critical QTL interval from 20 to 4.6 Mb by excluding shared haplotype regions and identified 11 nonsynonymous single-nucleotide polymorphisms in six candidate genes.
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掲載誌名 |
Genomics
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ISSN | 08887543
10898646
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cat書誌ID | AA10678346
AA11537587
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出版者 | Elsevier
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巻 | 88
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号 | 6
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開始ページ | 719
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終了ページ | 730
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発行日 | 2006-08-17
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権利情報 | Open Archive
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
AWAサポートセンター
先端酵素学研究所
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