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ID 110580
タイトルヨミ
ゼンシンセイ エリテマトーデス ノ ゲンイン イデンシ ノ カイメイ ト ソレ ニ モトズク シンキ チリョウホウ ノ カノウセイ
タイトル別表記
Defective antigen clearance and systemic lupus erythematosus
著者
安友, 康二 徳島大学医学部病態予防医学講座生体防御医学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
systemic lupus erythematosus
T-cells
DNase1
self-antigen
資料タイプ
学術雑誌論文
抄録
Autoimmune diseases are caused by defective genes, aberrant gene expression or regulation, and environmental factors. Autoimmune disease susceptibility is determined by the interplay of these factors, which eventually affect autoreactive lymphocyte activation status or cell death sensitivity. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a broad variety of clinical symptoms and autoantibody production against nucleic acids, typically double-stranded DNA. Several lines of evidence indicate SLE development has a strong genetic basis. Recent studies have shown that most of the peripheral CD4+ or CD8+ T-cells have a potential to respond to self-antigens and persistence of such self antigens in vivo can provoke human or murine SLE. These recent findings in basic and clinical immunology would cause us to reconsider the importance of antigen clearance and persistence as a cause of SLE. Thus, I would like to review the lymphocyte abnormal responses seen in SLE patients from the view point of defective self-antigen clearance.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
59
1-2
開始ページ
25
終了ページ
29
並び順
25
発行日
2003-04-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系