ID | 110628 |
著者 |
安友, 康二
Department of Parasitology and Immunology, The University of Tokushima School of Medicine
徳島大学 教育研究者総覧
KAKEN研究者をさがす
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キーワード | thymocytes
lineage commitment
T-cell receptor
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資料タイプ |
学術雑誌論文
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抄録 | A unique feature ofαβT-cell development is the central role played by clonally distributed T-cell receptors (TCR), which are encoded by somatically rearranged gene segments that produce a diverse, non-germline encoded set of receptors. Fate determination in individual T-cells is mediated by ligand-receptor signals that arise from unprogrammed genetic interactions, under conditions in which the relevant ligand concentration and the receptor affinity are not evolutionarily controlled. A precursor T-cell with a TCR that either fails to demonstrate appreciable self-reactivity or binds with high affinity to reasonably abundant self-peptide major histocompatibility complex (MHC)-ligands will undergo apoptosis. In contrast, a precursor T-cell that shows lower affinity to moderately abundant ligands will receive suitable signals for survival and maturation. Recently, we have developed a rapid in vitro two-step organ culture system that permits homogeneous populations of non-transformed precursor T-cells to undergo selective commitment to the CD4 or CD8 lineage. Using this model, we have shown that the choice of positively selected ab T-cells between the CD4 helper and CD8 cytotoxic lineages is regulated by the TCR signaling duration in response to self-peptides bound to the MHC.
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掲載誌名 |
The journal of medical investigation : JMI
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ISSN | 13431420
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cat書誌ID | AA11166929
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巻 | 49
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号 | 1-2
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開始ページ | 1
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終了ページ | 6
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並び順 | 1
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発行日 | 2002
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フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
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