ID 110679
著者
マツナガ, ヒロコ Second Department of Internal Medicine, The University of Tokushima School of Medicine
本田, 浩仁 Second Department of Internal Medicine, The University of Tokushima School of Medicine
久保, 謙一郎 Second Department of Internal Medicine, The University of Tokushima School of Medicine
サンノミヤ, カツタカ Second Department of Internal Medicine, The University of Tokushima School of Medicine
Cui, Xuezhi Second Department of Internal Medicine, The University of Tokushima School of Medicine
トヨタ, ヨシオ Second Department of Internal Medicine, The University of Tokushima School of Medicine
モリ, トシフミ Second Department of Internal Medicine, The University of Tokushima School of Medicine
六車, 直樹 Second Department of Internal Medicine, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
岡久, 稔也 Second Department of Internal Medicine, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
岡村, 誠介 Second Department of Internal Medicine, The University of Tokushima School of Medicine
清水, 一郎 Second Department of Internal Medicine, The University of Tokushima School of Medicine
伊東, 進 Second Department of Internal Medicine, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧
キーワード
chronic hepatitis
HCV
guanase
ALT
資料タイプ
学術雑誌論文
抄録
The study examines the clinical significance of guanase (GU) measurement inpatients with hepatitis C. 688 patients in whom either ALT was abnormal, or in whom HBsAg or HCVAb was detected in the serum, were enrolled into this study. The percentage of cases in which normal ALT while elevated GU was compared among the different disease groups. Then, the percentage of cases with normal ALT but elevated GU was compared between HBV and HCV groups. For the entire population, a significant correlation was observed between ALT and GU (r=0.872). The overall percentage of cases with normal ALT but elevated GU activity was 11.4%. In HCV group, 449 cases had normal ALT. Of these cases, 20.3% had elevated GU, while ALT was normal. Before 1989, no test to check donated blood for HCV antibody was available. However, screening of donated blood for high GU was associated with a reduced incidence of post-transfusion hepatitis. This is probably because following the screening, blood donated by patients with hepatitis C who had normal ALT but elevated GU was rejected. After the introduction of HCV antibody measurement, GU measurement is still useful to reveal the pathophysiological condition in-patients with chronic hepatitis type C.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
50
1-2
開始ページ
64
終了ページ
71
並び順
64
発行日
2003
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系