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ID 110663
著者
Ahsan, Mohammad Kamrul Department of Dermatology, The University of Tokushima School of Medicine
ウラノ, ヨシオ Department of Dermatology, The University of Tokushima School of Medicine
カトウ, ショウジ Department of Dermatology, The University of Tokushima School of Medicine
オオウラ, ハジム Department of Dermatology, The University of Tokushima School of Medicine
荒瀬, 誠治 Department of Dermatology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
thyroid hormone
thyroid hormone receptor
hair follicle
dermal papilla cells
資料タイプ
学術雑誌論文
抄録
To investigate the cellular basis of the action of thyroid hormone on hair follicles, we studied the immunohistochemical localization of thyroid hormone receptors (TRs) in human scalp skin using a mouse monoclonal antibody, TRα1 (C4) against TRs. Immunoreactive TRs were detected in the nuclei of the outer root sheath cells (ORSCs), dermal papilla cells (DPCs), fibrous sheath cells of hair follicles, hair arrector pili muscle cells and sebaceous gland cells. However, nuclei of hairmatrix cells were not clearly stained with TRα1 (C4). The epidermis showed positive nuclear staining by the antibody. Ductal and secretory portions of eccrine sweat glands were also stained with the antibody as we had expected. In the dermis, almost all the cell components including fibroblasts, vascular endothelial and smooth muscle cells, and Schwann cells were positively stained. Immunofluorescence also showed TRs expression in cultured ORSCs, DPCs, epidermal keratinocytes and dermal fibroblasts. L-triiodothyronine stimulated the proliferation and / or metabolism of all these four types of cells significantly, although there was variation at the rate of stimulation. Whereas, structurally similar, but metabolically inactive analog, reverse T3 had no effect. These results demonstrate the presence of thyroid hormone nuclear receptors in human hair follicles. Furthermore, the presence of TRs in different cell types in the skin suggests numerous direct effects of thyroid hormone on this target tissue.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
44
3-4
開始ページ
179
終了ページ
184
並び順
179
発行日
1998
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系