ID 110636
著者
Ewis, Ashraf A Department of Public Health, The University of Tokushima, School of Medicine|Department of Public Health and Occupational Medicine, School of Medicine, El-Minia University
Lee, Juwon Department of Public Health, The University of Tokushima, School of Medicine
奈路田, 拓史 Department of Urology, The University of Tokushima, School of Medicine
笹原, 賢司 Department of Public Health, The University of Tokushima, School of Medicine
佐野, 壽昭 Department of Pathology, The University of Tokushima, School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
香川, 征 Department of Urology, The University of Tokushima, School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
イワモト, テルアキ Department of Urology, School of Medicine, St. Marianna University
中堀, 豊 Department of Public Health, The University of Tokushima, School of Medicine
キーワード
prostate cancer
haplotypes
Y-chromosome
Japanese
DYS19
susceptibility
資料タイプ
学術雑誌論文
抄録
We studied the allele frequency distribution of the Y-chromosome linked tetranucleotide polymorphic microsatellite locus DYS19 in 90 prostate cancer Japanese patients from both Tokushima University hospital (Tokushima) and Saint Marianna University hospital (Kawasaki), Japan, comparing them to 99 matched male controls. Y-chromosomes from Japan as well as others from different geographical regions worldwide showed the five different alleles (A-E) with sizes varying from 186-202 bp, respectively. Comparison between DYS19 allelic frequency distribution among Japanese patients with prostate cancer and that of normal controls revealed significant differences regarding susceptibility or resistance to prostate cancer. We found that males with allele C of DYS19 are more susceptible to develop prostate cancer than males with other alleles (p=0.02). The Odds Ratio was 2.04 with a 95% confidence interval (0.75-2.42), compared with males having other alleles. In contrast, males with the D allele of DYS19 were less exposed to prostate cancer than other males (p=0.002); the Odds Ratio was 0.26 with a 95% confidence interval of (0.65-3.71). These findings support our hypothesis that male descendants from different Y-chromosomal origins are different regarding their susceptibility or resistance to develop prostate cancer (as a male-specific cancer).
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
49
1-2
開始ページ
56
終了ページ
60
並び順
56
発行日
2002
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系